The immune checkpoint protein PD-L1 induces and maintains regulatory T cells in glioblastoma

The immune checkpoint protein PD-L1 induces and maintains regulatory T cells in glioblastoma

Glioblastoma (GBM) promotes immunosuppression through upregulation of PD-L1 and regulatory T cell (Treg) expansion, but the association of these suppressive factors has not been well elucidated. Here, we investigate a role of PD-L1 in expanding Tregs and the value of targeting the PD-1 receptor to i...

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Bibliographic Details
Main Authors: Joseph DiDomenico, Jonathan B. Lamano, Daniel Oyon, Yuping Li, Dorina Veliceasa, Gurvinder Kaur, Leonel Ampie, Winward Choy, Jason B. Lamano, Orin Bloch
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:OncoImmunology
Subjects:
glioblastoma
immunotherapy
regulatory t cell
pd-11
pd-1
immunosuppression
nivolumab
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1448329

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