Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer
Background and objective It has been proven that multidrug resistance (MDR) is the main cause of chemotherapy failure in lung cancer. Research on emergence mechanisms of MDR has great clinical significance in improving the curative efficiency of lung cancer chemotherapy. Proteins encoded by the SLC2...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2012-01-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2012.01.04 |
| _version_ | 1829106362895826944 |
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| author | Ming LEI Qingshu CHENG Yachao ZHAO Tao LIU Xuejiao WANG Yingchun DENG Jing YANG Zhipei ZHANG |
| author_facet | Ming LEI Qingshu CHENG Yachao ZHAO Tao LIU Xuejiao WANG Yingchun DENG Jing YANG Zhipei ZHANG |
| author_sort | Ming LEI |
| collection | DOAJ |
| description | Background and objective It has been proven that multidrug resistance (MDR) is the main cause of chemotherapy failure in lung cancer. Research on emergence mechanisms of MDR has great clinical significance in improving the curative efficiency of lung cancer chemotherapy. Proteins encoded by the SLC22A18 gene, which is similar to the transmembrane transporter, may influence the sensitivity of chemotherapeutics as well as the metabolism and growth of cells. In addition, these proteins probably have some effect on the development of lung cancer MDR. The aim of the present study is to investigate the expression of SLC22A18 protein in non-small cell lung cancer (NSCLC) as well as in corresponding normal lung tissue. Furthermore, the relationship between SLC22A18 expression and pathological grade and TNM stage is analyzed. Methods The expression of SLC22A18 was detected by EnVinsion in 96 cases with NSCLC and in corresponding normal lung tissue. Statistical analysis was performed using SPSS 17.0 statistical software. Results SLC22A18 was mainly located in cell membrane and cytoplasm. The expression level of SLC22A18 in NSCLC was significantly higher than that in normal tissue (P<0.01). The positive rates in squamous cell lung cancer and lung adenocarcinoma were 68% and 78.2%, respectively (P<0.05). Moreover, the higher expression of SLC22A18 was associated with lower histological grade and later TNM stage (P<0.05). Conclusion SLC22A18 protein is overexpressed in NSCLC, and its expression is correlated with pathological grade and TNM stage. These findings provide the experimental basis for investigating the role of tumor and chemoresistance. |
| first_indexed | 2024-12-12T06:23:47Z |
| format | Article |
| id | doaj.art-06dc558b6c00405db6a3af5faca37617 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-12T06:23:47Z |
| publishDate | 2012-01-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-06dc558b6c00405db6a3af5faca376172022-12-22T00:34:50ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872012-01-01151172010.3779/j.issn.1009-3419.2012.01.04Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung CancerMing LEIQingshu CHENGYachao ZHAOTao LIUXuejiao WANGYingchun DENGJing YANGZhipei ZHANGBackground and objective It has been proven that multidrug resistance (MDR) is the main cause of chemotherapy failure in lung cancer. Research on emergence mechanisms of MDR has great clinical significance in improving the curative efficiency of lung cancer chemotherapy. Proteins encoded by the SLC22A18 gene, which is similar to the transmembrane transporter, may influence the sensitivity of chemotherapeutics as well as the metabolism and growth of cells. In addition, these proteins probably have some effect on the development of lung cancer MDR. The aim of the present study is to investigate the expression of SLC22A18 protein in non-small cell lung cancer (NSCLC) as well as in corresponding normal lung tissue. Furthermore, the relationship between SLC22A18 expression and pathological grade and TNM stage is analyzed. Methods The expression of SLC22A18 was detected by EnVinsion in 96 cases with NSCLC and in corresponding normal lung tissue. Statistical analysis was performed using SPSS 17.0 statistical software. Results SLC22A18 was mainly located in cell membrane and cytoplasm. The expression level of SLC22A18 in NSCLC was significantly higher than that in normal tissue (P<0.01). The positive rates in squamous cell lung cancer and lung adenocarcinoma were 68% and 78.2%, respectively (P<0.05). Moreover, the higher expression of SLC22A18 was associated with lower histological grade and later TNM stage (P<0.05). Conclusion SLC22A18 protein is overexpressed in NSCLC, and its expression is correlated with pathological grade and TNM stage. These findings provide the experimental basis for investigating the role of tumor and chemoresistance.http://dx.doi.org/10.3779/j.issn.1009-3419.2012.01.04Lung neoplasmsSLC22A18Immunohistochemistry |
| spellingShingle | Ming LEI Qingshu CHENG Yachao ZHAO Tao LIU Xuejiao WANG Yingchun DENG Jing YANG Zhipei ZHANG Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms SLC22A18 Immunohistochemistry |
| title | Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer |
| title_full | Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer |
| title_fullStr | Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer |
| title_full_unstemmed | Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer |
| title_short | Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer |
| title_sort | expression and its clinical significance of slc22a18 in non small cell lung cancer |
| topic | Lung neoplasms SLC22A18 Immunohistochemistry |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2012.01.04 |
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