TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway

TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway

Abstract Background The aim of this study is to explore the effects of TGF-β1 on autophagy and apoptosis induced by exogenous hydrogen peroxide (H2O2) in annulus fibrosus (AF) cells and possible signal pathways involved in this process. Methods AF cells were isolated from rat lumbar discs and subjec...

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Bibliographic Details
Main Authors: Binbin Ni, Hao Shen, Wei Wang, Hua Lu, Leisheng Jiang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Hydrogen peroxide
Autophagy
Apoptosis
ERK
Annulus fibrosus cells
Glutathion peroxidase-1
Online Access:http://link.springer.com/article/10.1186/s13018-019-1260-4

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