The Place of protease inhibitors in antiretroviral treatment
With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and rito...
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Format: | Article |
Language: | English |
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Elsevier
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Series: | Brazilian Journal of Infectious Diseases |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500012&lng=en&tlng=en |
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author | S.B. Tenore P.R.A. Ferreira |
author_facet | S.B. Tenore P.R.A. Ferreira |
author_sort | S.B. Tenore |
collection | DOAJ |
description | With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar efficacy among the various inhibitors with characteristics concerning the adverse events from each medicine. For the treatment of protease-resistant patients, darunavir and tipranavir showed good efficacy with higher genetic barrier to resistance. |
first_indexed | 2024-12-12T03:46:46Z |
format | Article |
id | doaj.art-06de6865394449c6a302ca89c19adea9 |
institution | Directory Open Access Journal |
issn | 1678-4391 |
language | English |
last_indexed | 2024-12-12T03:46:46Z |
publisher | Elsevier |
record_format | Article |
series | Brazilian Journal of Infectious Diseases |
spelling | doaj.art-06de6865394449c6a302ca89c19adea92022-12-22T00:39:32ZengElsevierBrazilian Journal of Infectious Diseases1678-439113537137410.1590/S1413-86702009000500012S1413-86702009000500012The Place of protease inhibitors in antiretroviral treatmentS.B. Tenore0P.R.A. Ferreira1Universidade Federal de São PauloUniversidade Federal de São PauloWith the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar efficacy among the various inhibitors with characteristics concerning the adverse events from each medicine. For the treatment of protease-resistant patients, darunavir and tipranavir showed good efficacy with higher genetic barrier to resistance.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500012&lng=en&tlng=enAIDSantiretroviral treatmentprotease inhibitors |
spellingShingle | S.B. Tenore P.R.A. Ferreira The Place of protease inhibitors in antiretroviral treatment Brazilian Journal of Infectious Diseases AIDS antiretroviral treatment protease inhibitors |
title | The Place of protease inhibitors in antiretroviral treatment |
title_full | The Place of protease inhibitors in antiretroviral treatment |
title_fullStr | The Place of protease inhibitors in antiretroviral treatment |
title_full_unstemmed | The Place of protease inhibitors in antiretroviral treatment |
title_short | The Place of protease inhibitors in antiretroviral treatment |
title_sort | place of protease inhibitors in antiretroviral treatment |
topic | AIDS antiretroviral treatment protease inhibitors |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500012&lng=en&tlng=en |
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