The Place of protease inhibitors in antiretroviral treatment

With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and rito...

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Main Authors: S.B. Tenore, P.R.A. Ferreira
Format: Article
Language:English
Published: Elsevier
Series:Brazilian Journal of Infectious Diseases
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500012&lng=en&tlng=en
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author S.B. Tenore
P.R.A. Ferreira
author_facet S.B. Tenore
P.R.A. Ferreira
author_sort S.B. Tenore
collection DOAJ
description With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar efficacy among the various inhibitors with characteristics concerning the adverse events from each medicine. For the treatment of protease-resistant patients, darunavir and tipranavir showed good efficacy with higher genetic barrier to resistance.
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spelling doaj.art-06de6865394449c6a302ca89c19adea92022-12-22T00:39:32ZengElsevierBrazilian Journal of Infectious Diseases1678-439113537137410.1590/S1413-86702009000500012S1413-86702009000500012The Place of protease inhibitors in antiretroviral treatmentS.B. Tenore0P.R.A. Ferreira1Universidade Federal de São PauloUniversidade Federal de São PauloWith the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar efficacy among the various inhibitors with characteristics concerning the adverse events from each medicine. For the treatment of protease-resistant patients, darunavir and tipranavir showed good efficacy with higher genetic barrier to resistance.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500012&lng=en&tlng=enAIDSantiretroviral treatmentprotease inhibitors
spellingShingle S.B. Tenore
P.R.A. Ferreira
The Place of protease inhibitors in antiretroviral treatment
Brazilian Journal of Infectious Diseases
AIDS
antiretroviral treatment
protease inhibitors
title The Place of protease inhibitors in antiretroviral treatment
title_full The Place of protease inhibitors in antiretroviral treatment
title_fullStr The Place of protease inhibitors in antiretroviral treatment
title_full_unstemmed The Place of protease inhibitors in antiretroviral treatment
title_short The Place of protease inhibitors in antiretroviral treatment
title_sort place of protease inhibitors in antiretroviral treatment
topic AIDS
antiretroviral treatment
protease inhibitors
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500012&lng=en&tlng=en
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