Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review
Introduction Metabolic dysfunction-associated fatty liver disease (MASLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease worldwide. Given that there is no pharmacological treatment for MASLD, it is imperative to understand whether lifestyle modifica...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-04-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/4/e079750.full |
| _version_ | 1797214999649714176 |
|---|---|
| author | David Armstrong Simon Oczkowski Constantine Jason Karvellas Joanna Dionne Kasey Moss Victor Gitman M Ines Pinto Sanchez Saumya Jayakumar Nazia Selzner |
| author_facet | David Armstrong Simon Oczkowski Constantine Jason Karvellas Joanna Dionne Kasey Moss Victor Gitman M Ines Pinto Sanchez Saumya Jayakumar Nazia Selzner |
| author_sort | David Armstrong |
| collection | DOAJ |
| description | Introduction Metabolic dysfunction-associated fatty liver disease (MASLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease worldwide. Given that there is no pharmacological treatment for MASLD, it is imperative to understand whether lifestyle modifications may improve biochemical and pathological outcomes. One commonly proposed dietary modification is the Mediterranean diet; however, vegetarianism may also be a promising intervention. Vegetarianism has been shown to be associated with reduced morbidity and mortality in metabolic syndrome outcomes in coronary artery disease and diabetes; however, the relationship between vegetarian diet and MASLD is less clear. In this scoping review, we will provide a comprehensive overview of the current body of evidence related to a vegetarian diet and MASLD.Methods and analysis The aim of this scoping review is to describe and summarise the current body of evidence related to MASLD and a vegetarian diet. This review will be conducted using Arksey and O’Malley’s framework. The literature review will be conducted using the following databases: SCOPUS, Web of Science, CINAHL-Plus, Cochrane Library and Medline. No restriction will be made on publication date. Included studies will encompass clinical trials and observational designs that examine effects or association of vegetarian diet in adults (≥16 years) and report on the incidence, prevalence or progression of MASLD. Grey literature, non-human studies and articles focusing on changes in a specific food or nutraceutical will be excluded. Articles must have an English-language abstract available to be considered for inclusion. Screening and data extraction will be conducted by two independent reviewers. The findings will be summarised with descriptive statistics.Ethics and dissemination Approval from a medical ethics committee is not required for this review. Once the review is complete, the findings will be submitted to a peer-reviewed journal. |
| first_indexed | 2024-04-24T11:23:06Z |
| format | Article |
| id | doaj.art-06dec8af2f6547d798b272cc8ef5baff |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-24T11:23:06Z |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-06dec8af2f6547d798b272cc8ef5baff2024-04-11T03:30:08ZengBMJ Publishing GroupBMJ Open2044-60552024-04-0114410.1136/bmjopen-2023-079750Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping reviewDavid Armstrong0Simon Oczkowski1Constantine Jason Karvellas2Joanna Dionne3Kasey Moss4Victor Gitman5M Ines Pinto Sanchez6Saumya Jayakumar7Nazia Selzner85 Department of Paediatrics, Monash University, Melbourne, Victoria, AustraliaHamilton Health Sciences, Hamilton, Ontario, CanadaDepartment of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDepartment of Health Research Methods, Evidence and Impact, McMaster University Department of Medicine, Hamilton, Ontario, CanadaDepartment of Medicine, McMaster University, Hamilton, Ontario, CanadaSchool of Pharmacy, University of Waterloo, Waterloo, Ontario, CanadaDepartment of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, CanadaDepartment of Medicine, Division of Gastroenterology, UBC, Vancouver, British Columbia, CanadaDepartment of Medicine, Division of Gastroenterology, University of Toronto, Toronto, Ontario, CanadaIntroduction Metabolic dysfunction-associated fatty liver disease (MASLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease worldwide. Given that there is no pharmacological treatment for MASLD, it is imperative to understand whether lifestyle modifications may improve biochemical and pathological outcomes. One commonly proposed dietary modification is the Mediterranean diet; however, vegetarianism may also be a promising intervention. Vegetarianism has been shown to be associated with reduced morbidity and mortality in metabolic syndrome outcomes in coronary artery disease and diabetes; however, the relationship between vegetarian diet and MASLD is less clear. In this scoping review, we will provide a comprehensive overview of the current body of evidence related to a vegetarian diet and MASLD.Methods and analysis The aim of this scoping review is to describe and summarise the current body of evidence related to MASLD and a vegetarian diet. This review will be conducted using Arksey and O’Malley’s framework. The literature review will be conducted using the following databases: SCOPUS, Web of Science, CINAHL-Plus, Cochrane Library and Medline. No restriction will be made on publication date. Included studies will encompass clinical trials and observational designs that examine effects or association of vegetarian diet in adults (≥16 years) and report on the incidence, prevalence or progression of MASLD. Grey literature, non-human studies and articles focusing on changes in a specific food or nutraceutical will be excluded. Articles must have an English-language abstract available to be considered for inclusion. Screening and data extraction will be conducted by two independent reviewers. The findings will be summarised with descriptive statistics.Ethics and dissemination Approval from a medical ethics committee is not required for this review. Once the review is complete, the findings will be submitted to a peer-reviewed journal.https://bmjopen.bmj.com/content/14/4/e079750.full |
| spellingShingle | David Armstrong Simon Oczkowski Constantine Jason Karvellas Joanna Dionne Kasey Moss Victor Gitman M Ines Pinto Sanchez Saumya Jayakumar Nazia Selzner Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review BMJ Open |
| title | Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review |
| title_full | Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review |
| title_fullStr | Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review |
| title_full_unstemmed | Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review |
| title_short | Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review |
| title_sort | evidence related to a vegetarian diet and metabolic dysfunction associated steatotic liver disease protocol for a scoping review |
| url | https://bmjopen.bmj.com/content/14/4/e079750.full |
| work_keys_str_mv | AT davidarmstrong evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview AT simonoczkowski evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview AT constantinejasonkarvellas evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview AT joannadionne evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview AT kaseymoss evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview AT victorgitman evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview AT minespintosanchez evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview AT saumyajayakumar evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview AT naziaselzner evidencerelatedtoavegetariandietandmetabolicdysfunctionassociatedsteatoticliverdiseaseprotocolforascopingreview |