Natural Killer cell recognition of melanoma: new clues for a more effective immunotherapy
Natural killer cells participate in the early immune response against melanoma and also contribute to the development of an adequate adaptive immune response by their crosstalk with dendritic cells and cytokine secretion. Melanoma resistance to conventional therapies together with its high immunogen...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00649/full |
| _version_ | 1828768917553676288 |
|---|---|
| author | Raquel eTarazona Esther eDuran Rafael eSolana |
| author_facet | Raquel eTarazona Esther eDuran Rafael eSolana |
| author_sort | Raquel eTarazona |
| collection | DOAJ |
| description | Natural killer cells participate in the early immune response against melanoma and also contribute to the development of an adequate adaptive immune response by their crosstalk with dendritic cells and cytokine secretion. Melanoma resistance to conventional therapies together with its high immunogenicity justifies the development of novel therapies aimed to stimulate effective immune responses against melanoma. However, melanoma cells frequently escape to CD8 T cell recognition by the down-regulation of major histocompatibility complex class I molecules. In this scenario, Natural killer cells emerge as potential candidates for melanoma immunotherapy due to their capacity to recognize and destroy melanoma cells expressing low levels of major histocompatibility complex class I molecules. In addition, the possibility to combine immune checkpoint blockade with other NK cell potentiating strategies (e.g. cytokine induction of activating receptors) has opened new perspectives in the potential use of adoptive NK cell-based immunotherapy in melanoma. |
| first_indexed | 2024-12-11T13:38:25Z |
| format | Article |
| id | doaj.art-06df6f72458f4b38b2da22528dda39c6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T13:38:25Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-06df6f72458f4b38b2da22528dda39c62022-12-22T01:04:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-01-01610.3389/fimmu.2015.00649173498Natural Killer cell recognition of melanoma: new clues for a more effective immunotherapyRaquel eTarazona0Esther eDuran1Rafael eSolana2University of ExtremaduraUniversity of ExtremaduraIMIBIC- Reina Sofia University Hospital-University of CordobaNatural killer cells participate in the early immune response against melanoma and also contribute to the development of an adequate adaptive immune response by their crosstalk with dendritic cells and cytokine secretion. Melanoma resistance to conventional therapies together with its high immunogenicity justifies the development of novel therapies aimed to stimulate effective immune responses against melanoma. However, melanoma cells frequently escape to CD8 T cell recognition by the down-regulation of major histocompatibility complex class I molecules. In this scenario, Natural killer cells emerge as potential candidates for melanoma immunotherapy due to their capacity to recognize and destroy melanoma cells expressing low levels of major histocompatibility complex class I molecules. In addition, the possibility to combine immune checkpoint blockade with other NK cell potentiating strategies (e.g. cytokine induction of activating receptors) has opened new perspectives in the potential use of adoptive NK cell-based immunotherapy in melanoma.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00649/fullAdoptive TransferImmunotherapyMelanomacheckpoint blockadeNatural Killer cells |
| spellingShingle | Raquel eTarazona Esther eDuran Rafael eSolana Natural Killer cell recognition of melanoma: new clues for a more effective immunotherapy Frontiers in Immunology Adoptive Transfer Immunotherapy Melanoma checkpoint blockade Natural Killer cells |
| title | Natural Killer cell recognition of melanoma: new clues for a more effective immunotherapy |
| title_full | Natural Killer cell recognition of melanoma: new clues for a more effective immunotherapy |
| title_fullStr | Natural Killer cell recognition of melanoma: new clues for a more effective immunotherapy |
| title_full_unstemmed | Natural Killer cell recognition of melanoma: new clues for a more effective immunotherapy |
| title_short | Natural Killer cell recognition of melanoma: new clues for a more effective immunotherapy |
| title_sort | natural killer cell recognition of melanoma new clues for a more effective immunotherapy |
| topic | Adoptive Transfer Immunotherapy Melanoma checkpoint blockade Natural Killer cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00649/full |
| work_keys_str_mv | AT raqueletarazona naturalkillercellrecognitionofmelanomanewcluesforamoreeffectiveimmunotherapy AT esthereduran naturalkillercellrecognitionofmelanomanewcluesforamoreeffectiveimmunotherapy AT rafaelesolana naturalkillercellrecognitionofmelanomanewcluesforamoreeffectiveimmunotherapy |