Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1
Background/objective: To understand the potential effects that severe acute respiratory syndrome coronavirus 2 (Sars-Cov-2) has on the endocrine system. Case report: A 56-year-old female presented with complaints of increased appetite, generalized weakness, facial and neck swelling and a non-pruriti...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Endocrine and Metabolic Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666396124000025 |
| _version_ | 1797272395005820928 |
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| author | Jenifer Centeno Gavica Mishelle Centeno Gavica Ricardo Franco-Sadud |
| author_facet | Jenifer Centeno Gavica Mishelle Centeno Gavica Ricardo Franco-Sadud |
| author_sort | Jenifer Centeno Gavica |
| collection | DOAJ |
| description | Background/objective: To understand the potential effects that severe acute respiratory syndrome coronavirus 2 (Sars-Cov-2) has on the endocrine system. Case report: A 56-year-old female presented with complaints of increased appetite, generalized weakness, facial and neck swelling and a non-pruritic rash across her chest, abdomen and back. Onset of symptoms coincided with a Sars-Cov-2 infection three months prior to current admission. The physical exam revealed cushingoid features. Laboratory results confirmed Cushing's disease. Imaging studies revealed an 11 mm right-sided pituitary adenoma and mild thickening of the adrenals bilaterally. Additionally, a 9.4 × 7.9 cm mass was identified in the caudate lobe of the liver concerning for neoplastic origin. Liver biopsy confirmed a well differentiated neuroendocrine tumor. Endoscopy revealed chronic gastritis with hemorrhage and multiple oozing duodenal ulcers, along with an elevated gastrin level. Subsequently, the patient received a diagnosis of multiple endocrine neoplasia type 1 (MEN-1), attributed to the presence of endocrine tumors involving the anterior pituitary and gastroenteropancreatic tract. Discussion: MEN-1 is a condition predisposing individual with two or more endocrine gland tumors primarily pituitary, parathyroid and gastroenteropancreatric tract. The clinical presentation varies and is often associated with hormone overproduction and tumor location. Coronavirus disease 2019 (COVID-19) is caused by Sars-Cov-2. Studies have shown to link Sars-Cov-2 with endocrinopathy. Conclusion: The impact of SARS-CoV-2 extends beyond the respiratory system, highlighting the need for further research into its direct influence on the endocrine system. |
| first_indexed | 2024-03-07T14:27:43Z |
| format | Article |
| id | doaj.art-06e12dd2a24140a7a50714f0f9214f37 |
| institution | Directory Open Access Journal |
| issn | 2666-3961 |
| language | English |
| last_indexed | 2024-03-07T14:27:43Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj.art-06e12dd2a24140a7a50714f0f9214f372024-03-06T05:28:47ZengElsevierEndocrine and Metabolic Science2666-39612024-03-0114100158Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1Jenifer Centeno Gavica0Mishelle Centeno Gavica1Ricardo Franco-Sadud2Department of Internal Medicine, NCH Healthcare System, 311 9th St. N. Suite 300, Naples, FL 34102, United States of America; Corresponding author at: 311 9th St. N. Suite 300, Naples, FL 34102, United States of America.Department of Internal Medicine, Stony Brook University Hospital, Health Science Ctr Ste T16020, Stony Brook, NY 11794, United States of AmericaDepartment of Internal Medicine, NCH Healthcare System, 311 9th St. N. Suite 300, Naples, FL 34102, United States of AmericaBackground/objective: To understand the potential effects that severe acute respiratory syndrome coronavirus 2 (Sars-Cov-2) has on the endocrine system. Case report: A 56-year-old female presented with complaints of increased appetite, generalized weakness, facial and neck swelling and a non-pruritic rash across her chest, abdomen and back. Onset of symptoms coincided with a Sars-Cov-2 infection three months prior to current admission. The physical exam revealed cushingoid features. Laboratory results confirmed Cushing's disease. Imaging studies revealed an 11 mm right-sided pituitary adenoma and mild thickening of the adrenals bilaterally. Additionally, a 9.4 × 7.9 cm mass was identified in the caudate lobe of the liver concerning for neoplastic origin. Liver biopsy confirmed a well differentiated neuroendocrine tumor. Endoscopy revealed chronic gastritis with hemorrhage and multiple oozing duodenal ulcers, along with an elevated gastrin level. Subsequently, the patient received a diagnosis of multiple endocrine neoplasia type 1 (MEN-1), attributed to the presence of endocrine tumors involving the anterior pituitary and gastroenteropancreatic tract. Discussion: MEN-1 is a condition predisposing individual with two or more endocrine gland tumors primarily pituitary, parathyroid and gastroenteropancreatric tract. The clinical presentation varies and is often associated with hormone overproduction and tumor location. Coronavirus disease 2019 (COVID-19) is caused by Sars-Cov-2. Studies have shown to link Sars-Cov-2 with endocrinopathy. Conclusion: The impact of SARS-CoV-2 extends beyond the respiratory system, highlighting the need for further research into its direct influence on the endocrine system.http://www.sciencedirect.com/science/article/pii/S2666396124000025MEN-1COVID-19Sars-Cov-2 |
| spellingShingle | Jenifer Centeno Gavica Mishelle Centeno Gavica Ricardo Franco-Sadud Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1 Endocrine and Metabolic Science MEN-1 COVID-19 Sars-Cov-2 |
| title | Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1 |
| title_full | Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1 |
| title_fullStr | Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1 |
| title_full_unstemmed | Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1 |
| title_short | Clinical manifestation of cushing's disease after COVID-19 infection leading to the diagnosis of multiple endocrine neoplasia type 1 |
| title_sort | clinical manifestation of cushing s disease after covid 19 infection leading to the diagnosis of multiple endocrine neoplasia type 1 |
| topic | MEN-1 COVID-19 Sars-Cov-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2666396124000025 |
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