Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3...

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Bibliographic Details
Main Authors: S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin
Format: Article
Language:English
Published: Nature Portfolio 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20073-8
Description
Summary:Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3, implicated for the maturation of both cell types.
ISSN:2041-1723

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