Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20073-8 |
| _version_ | 1818344818182455296 |
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| author | S. Harsha Krovi Jingjing Zhang Mary Jessamine Michaels-Foster Tonya Brunetti Liyen Loh James Scott-Browne Laurent Gapin |
| author_facet | S. Harsha Krovi Jingjing Zhang Mary Jessamine Michaels-Foster Tonya Brunetti Liyen Loh James Scott-Browne Laurent Gapin |
| author_sort | S. Harsha Krovi |
| collection | DOAJ |
| description | Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3, implicated for the maturation of both cell types. |
| first_indexed | 2024-12-13T16:52:31Z |
| format | Article |
| id | doaj.art-06e13866d71d4727a0acfddef21305ab |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:52:31Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-06e13866d71d4727a0acfddef21305ab2022-12-21T23:38:00ZengNature PortfolioNature Communications2041-17232020-12-0111111510.1038/s41467-020-20073-8Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cellsS. Harsha Krovi0Jingjing Zhang1Mary Jessamine Michaels-Foster2Tonya Brunetti3Liyen Loh4James Scott-Browne5Laurent Gapin6Department of Immunology and Microbiology, University of Colorado Anschutz Medical CampusDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical CampusDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical CampusDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical CampusDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical CampusDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical CampusDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical CampusInnate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental regulation, with a transcription factor, Hivep3, implicated for the maturation of both cell types.https://doi.org/10.1038/s41467-020-20073-8 |
| spellingShingle | S. Harsha Krovi Jingjing Zhang Mary Jessamine Michaels-Foster Tonya Brunetti Liyen Loh James Scott-Browne Laurent Gapin Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells Nature Communications |
| title | Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells |
| title_full | Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells |
| title_fullStr | Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells |
| title_full_unstemmed | Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells |
| title_short | Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells |
| title_sort | thymic inkt single cell analyses unmask the common developmental program of mouse innate t cells |
| url | https://doi.org/10.1038/s41467-020-20073-8 |
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