Recent Understandings of Pet Allergies [version 1; referees: 2 approved]
Allergic reactions to pets have been recognized for at least a hundred years. Yet our understanding of the effects of all of the interactions between pet exposures and human immune responses continues to grow. Allergists, epidemiologists, and immunologists have spent years trying to better understan...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2016-01-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/5-108/v1 |
| _version_ | 1818303626179772416 |
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| author | Dennis Ownby Christine Cole Johnson |
| author_facet | Dennis Ownby Christine Cole Johnson |
| author_sort | Dennis Ownby |
| collection | DOAJ |
| description | Allergic reactions to pets have been recognized for at least a hundred years. Yet our understanding of the effects of all of the interactions between pet exposures and human immune responses continues to grow. Allergists, epidemiologists, and immunologists have spent years trying to better understand how exposures to pet allergens lead to allergic sensitization (the production of allergen-specific immunoglobulin class E [IgE] antibodies) and subsequent allergic disease. A major new development in this understanding is the recognition that pet exposures consist of not only allergen exposures but also changes in microbial exposures. Exposures to certain pet-associated microbes, especially in the neonatal period, appear to be able to dramatically alter how a child’s immune system develops and this in turn reduces the risk of allergic sensitization and disease. An exciting challenge in the next few years will be to see whether these changes can be developed into a realistic preventative strategy with the expectation of significantly reducing allergic disease, especially asthma. |
| first_indexed | 2024-12-13T05:57:47Z |
| format | Article |
| id | doaj.art-06e13acb42d44454b2f32a950eae6e05 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-13T05:57:47Z |
| publishDate | 2016-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-06e13acb42d44454b2f32a950eae6e052022-12-21T23:57:24ZengF1000 Research LtdF1000Research2046-14022016-01-01510.12688/f1000research.7044.17583Recent Understandings of Pet Allergies [version 1; referees: 2 approved]Dennis Ownby0Christine Cole Johnson1Georgia Regents University, Augusta, GA, USADepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, USAAllergic reactions to pets have been recognized for at least a hundred years. Yet our understanding of the effects of all of the interactions between pet exposures and human immune responses continues to grow. Allergists, epidemiologists, and immunologists have spent years trying to better understand how exposures to pet allergens lead to allergic sensitization (the production of allergen-specific immunoglobulin class E [IgE] antibodies) and subsequent allergic disease. A major new development in this understanding is the recognition that pet exposures consist of not only allergen exposures but also changes in microbial exposures. Exposures to certain pet-associated microbes, especially in the neonatal period, appear to be able to dramatically alter how a child’s immune system develops and this in turn reduces the risk of allergic sensitization and disease. An exciting challenge in the next few years will be to see whether these changes can be developed into a realistic preventative strategy with the expectation of significantly reducing allergic disease, especially asthma.http://f1000research.com/articles/5-108/v1Allergy & HypersensitivityAnimal GeneticsClinical ImmunologyEpidemiologyImmunopharmacology & Hematologic Pharmacology |
| spellingShingle | Dennis Ownby Christine Cole Johnson Recent Understandings of Pet Allergies [version 1; referees: 2 approved] F1000Research Allergy & Hypersensitivity Animal Genetics Clinical Immunology Epidemiology Immunopharmacology & Hematologic Pharmacology |
| title | Recent Understandings of Pet Allergies [version 1; referees: 2 approved] |
| title_full | Recent Understandings of Pet Allergies [version 1; referees: 2 approved] |
| title_fullStr | Recent Understandings of Pet Allergies [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent Understandings of Pet Allergies [version 1; referees: 2 approved] |
| title_short | Recent Understandings of Pet Allergies [version 1; referees: 2 approved] |
| title_sort | recent understandings of pet allergies version 1 referees 2 approved |
| topic | Allergy & Hypersensitivity Animal Genetics Clinical Immunology Epidemiology Immunopharmacology & Hematologic Pharmacology |
| url | http://f1000research.com/articles/5-108/v1 |
| work_keys_str_mv | AT dennisownby recentunderstandingsofpetallergiesversion1referees2approved AT christinecolejohnson recentunderstandingsofpetallergiesversion1referees2approved |