In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing
Abstract Background Excessive oxidative stress at the wound sites always leads to a prolonged healing and even causes chronic inflammatory wounds. Therefore, antioxidative dressings with multiple features are desired to improve wound healing performance. Herein, we fabricated a ROS-scavenging hybrid...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-01879-2 |
| _version_ | 1797845785959727104 |
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| author | Xuan Chen Yihui Zhang Wei Yu Wenkai Zhang Haozheng Tang Wei-En Yuan |
| author_facet | Xuan Chen Yihui Zhang Wei Yu Wenkai Zhang Haozheng Tang Wei-En Yuan |
| author_sort | Xuan Chen |
| collection | DOAJ |
| description | Abstract Background Excessive oxidative stress at the wound sites always leads to a prolonged healing and even causes chronic inflammatory wounds. Therefore, antioxidative dressings with multiple features are desired to improve wound healing performance. Herein, we fabricated a ROS-scavenging hybrid hydrogel by incorporating mussel-inspired fullerene nanocomposites (C60@PDA) into gelatin methacryloyl (GelMA) hydrogel. Results The developed C60@PDA/GelMA hydrogel showed a sustainable free radical scavenging ability, and eliminated ROS to protect cells against external oxidative stress damage. Besides, the hydrogel presented favorable cytocompatibility, hemocompatibility, and antibacterial ability in vitro. Furthermore, in a mouse full-thickness wound defect model, the in situ forming hybrid hydrogel accelerated wound closure by 38.5% and 42.9% on day 3 and day 7 over the control. Histological results demonstrated that hybrid hydrogels effectively enhanced wound healing on re-epithelialization, collagen deposition and angiogenesis. Conclusion Collectively, the C60@PDA/GelMA hydrogel could be a promising dressing for promoting cutaneous wound repair. |
| first_indexed | 2024-04-09T17:44:35Z |
| format | Article |
| id | doaj.art-06e141d57f1341288d89c33c6f1a041e |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-09T17:44:35Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-06e141d57f1341288d89c33c6f1a041e2023-04-16T11:24:13ZengBMCJournal of Nanobiotechnology1477-31552023-04-0121111510.1186/s12951-023-01879-2In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healingXuan Chen0Yihui Zhang1Wei Yu2Wenkai Zhang3Haozheng Tang4Wei-En Yuan5Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong UniversityEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong UniversityEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong UniversityEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong UniversityDepartment of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityEngineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong UniversityAbstract Background Excessive oxidative stress at the wound sites always leads to a prolonged healing and even causes chronic inflammatory wounds. Therefore, antioxidative dressings with multiple features are desired to improve wound healing performance. Herein, we fabricated a ROS-scavenging hybrid hydrogel by incorporating mussel-inspired fullerene nanocomposites (C60@PDA) into gelatin methacryloyl (GelMA) hydrogel. Results The developed C60@PDA/GelMA hydrogel showed a sustainable free radical scavenging ability, and eliminated ROS to protect cells against external oxidative stress damage. Besides, the hydrogel presented favorable cytocompatibility, hemocompatibility, and antibacterial ability in vitro. Furthermore, in a mouse full-thickness wound defect model, the in situ forming hybrid hydrogel accelerated wound closure by 38.5% and 42.9% on day 3 and day 7 over the control. Histological results demonstrated that hybrid hydrogels effectively enhanced wound healing on re-epithelialization, collagen deposition and angiogenesis. Conclusion Collectively, the C60@PDA/GelMA hydrogel could be a promising dressing for promoting cutaneous wound repair.https://doi.org/10.1186/s12951-023-01879-2Hybrid hydrogelFullerenePolydopamineAntioxidantWound healing |
| spellingShingle | Xuan Chen Yihui Zhang Wei Yu Wenkai Zhang Haozheng Tang Wei-En Yuan In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing Journal of Nanobiotechnology Hybrid hydrogel Fullerene Polydopamine Antioxidant Wound healing |
| title | In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing |
| title_full | In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing |
| title_fullStr | In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing |
| title_full_unstemmed | In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing |
| title_short | In situ forming ROS-scavenging hybrid hydrogel loaded with polydopamine-modified fullerene nanocomposites for promoting skin wound healing |
| title_sort | in situ forming ros scavenging hybrid hydrogel loaded with polydopamine modified fullerene nanocomposites for promoting skin wound healing |
| topic | Hybrid hydrogel Fullerene Polydopamine Antioxidant Wound healing |
| url | https://doi.org/10.1186/s12951-023-01879-2 |
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