Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar
Abstract Aims/Introduction Painful diabetic peripheral neuropathy (PDPN) has a significant impact on the patient's quality of life. The prevalence of PDPN in the Middle East and North Africa region has been reported to be almost double that of populations in the UK. We sought to determine the p...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-11-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13037 |
| _version_ | 1818865970099257344 |
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| author | Georgios Ponirakis Tarik Elhadd Subitha Chinnaiyan Zeinab Dabbous Mashhood Siddiqui Hamad Al‐muhannadi Ioannis Petropoulos Adnan Khan Khaled AE Ashawesh Khaled MO Dukhan Ziyad R Mahfoud Christopher Murgatroyd Mark Slevin Rayaz A Malik |
| author_facet | Georgios Ponirakis Tarik Elhadd Subitha Chinnaiyan Zeinab Dabbous Mashhood Siddiqui Hamad Al‐muhannadi Ioannis Petropoulos Adnan Khan Khaled AE Ashawesh Khaled MO Dukhan Ziyad R Mahfoud Christopher Murgatroyd Mark Slevin Rayaz A Malik |
| author_sort | Georgios Ponirakis |
| collection | DOAJ |
| description | Abstract Aims/Introduction Painful diabetic peripheral neuropathy (PDPN) has a significant impact on the patient's quality of life. The prevalence of PDPN in the Middle East and North Africa region has been reported to be almost double that of populations in the UK. We sought to determine the prevalence of PDPN and its associated factors in type 2 diabetes mellitus patients attending secondary care in Qatar. Materials and Methods This was a cross‐sectional study of 1,095 participants with type 2 diabetes mellitus attending Qatar's two national diabetes centers. PDPN and impaired vibration perception on the pulp of the large toes were assessed using the Douleur Neuropathique en 4 questionnaire with a cut‐off ≥4 and the neurothesiometer with a cut‐off ≥15 V, respectively. Results The prevalence of PDPN was 34.5% (95% confidence interval [CI] 31.7–37.3), but 80% of these patients had not previously been diagnosed or treated for this condition. Arabs had a higher prevalence of PDPN compared with South Asians (P < 0.05). PDPN was associated with impaired vibration perception adjusted odds ratio (AOR) 4.42 (95% CI 2.92–6.70), smoking AOR 2.43 (95% CI 1.43–4.15), obesity AOR 1.74 (95% CI 1.13–2.66), being female AOR 1.65 (95% CI: 1.03–2.64) and duration of diabetes AOR 1.08 (95% CI 1.05–1.11). Age, poor glycemic control, hypertension, physical activity and proteinuria showed no association with PDPN. Conclusions PDPN occurs in one‐third of type 2 diabetes mellitus patients attending secondary care in Qatar, but the majority have not been diagnosed. Arabs are at higher risk for PDPN. Impaired vibration perception, obesity and smoking are associated with PDPN in Qatar. |
| first_indexed | 2024-12-19T10:56:00Z |
| format | Article |
| id | doaj.art-06e35feef74e4bcba371bf8afcf8718c |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-19T10:56:00Z |
| publishDate | 2019-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-06e35feef74e4bcba371bf8afcf8718c2022-12-21T20:24:49ZengWileyJournal of Diabetes Investigation2040-11162040-11242019-11-011061558156410.1111/jdi.13037Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in QatarGeorgios Ponirakis0Tarik Elhadd1Subitha Chinnaiyan2Zeinab Dabbous3Mashhood Siddiqui4Hamad Al‐muhannadi5Ioannis Petropoulos6Adnan Khan7Khaled AE Ashawesh8Khaled MO Dukhan9Ziyad R Mahfoud10Christopher Murgatroyd11Mark Slevin12Rayaz A Malik13Weill Cornell Medicine‐Qatar Qatar Foundation Education City Doha QatarNational Diabetes and Endocrine Centre Hamad Medical Corporation Hamad General HospitalDoha QatarNational Diabetes and Endocrine Centre Hamad Medical Corporation Hamad General HospitalDoha QatarNational Diabetes and Endocrine Centre Hamad Medical Corporation Hamad General HospitalDoha QatarNational Diabetes and Endocrine Centre Hamad Medical Corporation Hamad General HospitalDoha QatarWeill Cornell Medicine‐Qatar Qatar Foundation Education City Doha QatarWeill Cornell Medicine‐Qatar Qatar Foundation Education City Doha QatarWeill Cornell Medicine‐Qatar Qatar Foundation Education City Doha QatarNational Diabetes and Endocrine Centre Hamad Medical Corporation Al‐Wakra Hospital Doha QatarNational Diabetes and Endocrine Centre Hamad Medical Corporation Al‐Wakra Hospital Doha QatarWeill Cornell Medicine‐Qatar Qatar Foundation Education City Doha QatarFaculty of Science and Engineering Manchester Metropolitan University Manchester UKFaculty of Science and Engineering Manchester Metropolitan University Manchester UKWeill Cornell Medicine‐Qatar Qatar Foundation Education City Doha QatarAbstract Aims/Introduction Painful diabetic peripheral neuropathy (PDPN) has a significant impact on the patient's quality of life. The prevalence of PDPN in the Middle East and North Africa region has been reported to be almost double that of populations in the UK. We sought to determine the prevalence of PDPN and its associated factors in type 2 diabetes mellitus patients attending secondary care in Qatar. Materials and Methods This was a cross‐sectional study of 1,095 participants with type 2 diabetes mellitus attending Qatar's two national diabetes centers. PDPN and impaired vibration perception on the pulp of the large toes were assessed using the Douleur Neuropathique en 4 questionnaire with a cut‐off ≥4 and the neurothesiometer with a cut‐off ≥15 V, respectively. Results The prevalence of PDPN was 34.5% (95% confidence interval [CI] 31.7–37.3), but 80% of these patients had not previously been diagnosed or treated for this condition. Arabs had a higher prevalence of PDPN compared with South Asians (P < 0.05). PDPN was associated with impaired vibration perception adjusted odds ratio (AOR) 4.42 (95% CI 2.92–6.70), smoking AOR 2.43 (95% CI 1.43–4.15), obesity AOR 1.74 (95% CI 1.13–2.66), being female AOR 1.65 (95% CI: 1.03–2.64) and duration of diabetes AOR 1.08 (95% CI 1.05–1.11). Age, poor glycemic control, hypertension, physical activity and proteinuria showed no association with PDPN. Conclusions PDPN occurs in one‐third of type 2 diabetes mellitus patients attending secondary care in Qatar, but the majority have not been diagnosed. Arabs are at higher risk for PDPN. Impaired vibration perception, obesity and smoking are associated with PDPN in Qatar.https://doi.org/10.1111/jdi.13037ObesityPainful diabetic peripheral neuropathyType 2 diabetes |
| spellingShingle | Georgios Ponirakis Tarik Elhadd Subitha Chinnaiyan Zeinab Dabbous Mashhood Siddiqui Hamad Al‐muhannadi Ioannis Petropoulos Adnan Khan Khaled AE Ashawesh Khaled MO Dukhan Ziyad R Mahfoud Christopher Murgatroyd Mark Slevin Rayaz A Malik Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar Journal of Diabetes Investigation Obesity Painful diabetic peripheral neuropathy Type 2 diabetes |
| title | Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar |
| title_full | Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar |
| title_fullStr | Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar |
| title_full_unstemmed | Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar |
| title_short | Prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in Qatar |
| title_sort | prevalence and risk factors for painful diabetic neuropathy in secondary healthcare in qatar |
| topic | Obesity Painful diabetic peripheral neuropathy Type 2 diabetes |
| url | https://doi.org/10.1111/jdi.13037 |
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