Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation in Aged Mice
As populations around the world age, interest in healthy aging is growing. One of the first physical changes that occurs with aging is the loss of muscle mass and strength, termed sarcopenia. Sarcopenia limits the activity of older people, reduces their quality of life, and increases the likelihood...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/18/2257 |
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| author | Hyun-Ji Oh Heegu Jin Jeong-Yong Lee Boo-Yong Lee |
| author_facet | Hyun-Ji Oh Heegu Jin Jeong-Yong Lee Boo-Yong Lee |
| author_sort | Hyun-Ji Oh |
| collection | DOAJ |
| description | As populations around the world age, interest in healthy aging is growing. One of the first physical changes that occurs with aging is the loss of muscle mass and strength, termed sarcopenia. Sarcopenia limits the activity of older people, reduces their quality of life, and increases the likelihood of their developing disease. In the present study, we aimed to evaluate the effects of the ingestion of acid-hydrolyzed silk peptide (SP) on the muscle mass and strength of mice of >22 months of age with naturally occurring sarcopenia, and to identify the mechanisms involved. The daily administration of SP for 8 weeks increased the activation of the Akt/mTOR/FoxO3a signaling pathways and increased the muscle mass and strength of the old mice. In addition, SP inhibited oxidative stress and inflammation in muscle, which are direct causes of sarcopenia. Therefore, SP represents a promising potential treatment for sarcopenia that may improve the healthy lifespan and quality of life of older people. |
| first_indexed | 2024-03-10T22:55:54Z |
| format | Article |
| id | doaj.art-06e374988a364c87a6cc44884bbd84f5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T22:55:54Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-06e374988a364c87a6cc44884bbd84f52023-11-19T09:59:31ZengMDPI AGCells2073-44092023-09-011218225710.3390/cells12182257Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation in Aged MiceHyun-Ji Oh0Heegu Jin1Jeong-Yong Lee2Boo-Yong Lee3Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam 13488, Republic of KoreaDepartment of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam 13488, Republic of KoreaWorldway Co., Ltd., Sejong 30003, Republic of KoreaDepartment of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam 13488, Republic of KoreaAs populations around the world age, interest in healthy aging is growing. One of the first physical changes that occurs with aging is the loss of muscle mass and strength, termed sarcopenia. Sarcopenia limits the activity of older people, reduces their quality of life, and increases the likelihood of their developing disease. In the present study, we aimed to evaluate the effects of the ingestion of acid-hydrolyzed silk peptide (SP) on the muscle mass and strength of mice of >22 months of age with naturally occurring sarcopenia, and to identify the mechanisms involved. The daily administration of SP for 8 weeks increased the activation of the Akt/mTOR/FoxO3a signaling pathways and increased the muscle mass and strength of the old mice. In addition, SP inhibited oxidative stress and inflammation in muscle, which are direct causes of sarcopenia. Therefore, SP represents a promising potential treatment for sarcopenia that may improve the healthy lifespan and quality of life of older people.https://www.mdpi.com/2073-4409/12/18/2257acid-hydrolyzed silk peptidesarcopeniaAktmTORFoxO3asignaling pathway |
| spellingShingle | Hyun-Ji Oh Heegu Jin Jeong-Yong Lee Boo-Yong Lee Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation in Aged Mice Cells acid-hydrolyzed silk peptide sarcopenia Akt mTOR FoxO3a signaling pathway |
| title | Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation in Aged Mice |
| title_full | Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation in Aged Mice |
| title_fullStr | Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation in Aged Mice |
| title_full_unstemmed | Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation in Aged Mice |
| title_short | Silk Peptide Ameliorates Sarcopenia through the Regulation of Akt/mTOR/FoxO3a Signaling Pathways and the Inhibition of Low-Grade Chronic Inflammation in Aged Mice |
| title_sort | silk peptide ameliorates sarcopenia through the regulation of akt mtor foxo3a signaling pathways and the inhibition of low grade chronic inflammation in aged mice |
| topic | acid-hydrolyzed silk peptide sarcopenia Akt mTOR FoxO3a signaling pathway |
| url | https://www.mdpi.com/2073-4409/12/18/2257 |
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