Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism

Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism

Abstract Background Gastric cancer (GC) is a commonly occurring human malignancy. The 5-fluorouracil (5-Fu) is a first-line anti-gastric cancer agent. However, a large number of GC patients developed 5-Fu resistance. Currently, the roles and molecular mechanisms of the lncRNA-SNHG16-modulated 5-Fu r...

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Bibliographic Details
Main Authors: Yan Ding, Sujie Gao, Jiabin Zheng, Xuebo Chen
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cancer & Metabolism
Subjects:
lncRNA SNHG16
PTBP1
Warburg effect
Glycolysis
5-Fu resistance
Online Access:https://doi.org/10.1186/s40170-022-00293-w

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