Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling

Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling

Vascular calcification is prominent in patients with chronic kidney disease (CKD) and is a strong predictor of cardiovascular mortality in the CKD population. However, the mechanism underlying CKD-associated vascular calcification remains unclear. To identify potential therapeutic targets, a 5/6 nep...

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Bibliographic Details
Main Authors: Qiong Xiao, Yun Tang, Haojun Luo, Sipei Chen, Rong Chen, Zhe Yan, Lei Pu, Li Wang, Guisen Li, Yi Li
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Renal Failure
Subjects:
Chronic kidney disease
microRNA
sclerostin
vascular calcification
vascular smooth muscle cells
Wnt signaling pathway
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2022.2114370

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