Effect of food on the pharmacokinetics of zoliflodacin granules for oral suspension: Phase I open‐label randomized cross‐over study in healthy subjects
Abstract Gonorrhea is a sexually transmitted infection for which antibiotic treatment options have declined due to increasing antibiotic resistance. Zoliflodacin, an investigational oral spiropyrimidinetrione antibiotic with activity against Neisseria gonorrhoeae strains that are multidrug‐resistant...
Main Authors: | Alison Luckey, Emilie Alirol, Sophie Delhomme, John O'Donnell, Esther Bettiol, John Mueller, Seamus O'Brien, Jean‐Yves Gillon |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2023-05-01
|
Series: | Clinical and Translational Science |
Online Access: | https://doi.org/10.1111/cts.13487 |
Similar Items
-
Zoliflodacin: A hope to treat antibiotic-resistant Neisseria gonorrhoeae
by: Mohammad Reza Mohammadi
Published: (2023-03-01) -
Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model
by: Susanne Jacobsson, et al.
Published: (2022-04-01) -
A 2.8 Å Structure of Zoliflodacin in a DNA Cleavage Complex with <i>Staphylococcus aureus</i> DNA Gyrase
by: Harry Morgan, et al.
Published: (2023-01-01) -
Zoliflodacin, A Novel Antimirobial Agent Against neisseria Gonorhoeae: A Systematic Rreview of Quasi-Experimental Studies
by: Franklind Matthew, et al.
Published: (2024-03-01) -
Gonococcal resistance to zoliflodacin could emerge via transformation from commensal Neisseria species. An in-vitro transformation study
by: Saïd Abdellati, et al.
Published: (2024-01-01)