Value of Contrast-Enhanced Ultrasound in Partially Cystic Papillary Thyroid Carcinomas
Partially cystic papillary thyroid carcinomas (PCPTCs) are rarely reported papillary thyroid carcinomas (PTCs) and are usually misdiagnosed as benign nodules. The objective of this study was to provide the various sonographic characteristics of partially cystic thyroid nodules for differentiation be...
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.783670/full |
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| author | Fengkai Fang Yi Gong Liyan Liao Fei Ye Zhongkun Zuo Zhang Qi Xiaodu Li Chengcheng Niu |
| author_facet | Fengkai Fang Yi Gong Liyan Liao Fei Ye Zhongkun Zuo Zhang Qi Xiaodu Li Chengcheng Niu |
| author_sort | Fengkai Fang |
| collection | DOAJ |
| description | Partially cystic papillary thyroid carcinomas (PCPTCs) are rarely reported papillary thyroid carcinomas (PTCs) and are usually misdiagnosed as benign nodules. The objective of this study was to provide the various sonographic characteristics of partially cystic thyroid nodules for differentiation between malignant and benign nodules, including those for conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS). Twenty-three PCPTC patients and 37 nodular goiter patients were enrolled in this study. We evaluated the size, cystic percentage, solid echogenicity, calcification, vascularity, and CEUS parameters for each nodule. The final diagnosis of all patients was confirmed via surgery. Univariate analysis demonstrated that compared with benign nodular goiters, PCPTCs more frequently presented with calcification, hypoechogenicity of the solid part, hypoenhancement, heterogeneous enhancement, centrifugal perfusion, peak intensity index <1, time to peak index ≥1, and area under the curve index <1 on preoperative US and CEUS. Binary logistic regression analysis demonstrated that heterogeneous enhancement, centrifugal perfusion, and peak intensity index <1 are independent CEUS characteristics related to malignant PCPTCs and can be used for their differentiation from benign nodular goiters (all p < 0.05). Our study indicated that preoperative CEUS characteristics may serve as a useful tool to distinguish malignant PCPTCs from benign thyroid nodules. |
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| language | English |
| last_indexed | 2024-12-17T13:26:25Z |
| publishDate | 2021-12-01 |
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| spelling | doaj.art-06e70d68830e45069e4dba49dbb9308d2022-12-21T21:46:42ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-12-011210.3389/fendo.2021.783670783670Value of Contrast-Enhanced Ultrasound in Partially Cystic Papillary Thyroid CarcinomasFengkai Fang0Yi Gong1Liyan Liao2Fei Ye3Zhongkun Zuo4Zhang Qi5Xiaodu Li6Chengcheng Niu7Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thyroid Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thyroid Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thyroid Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaPartially cystic papillary thyroid carcinomas (PCPTCs) are rarely reported papillary thyroid carcinomas (PTCs) and are usually misdiagnosed as benign nodules. The objective of this study was to provide the various sonographic characteristics of partially cystic thyroid nodules for differentiation between malignant and benign nodules, including those for conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS). Twenty-three PCPTC patients and 37 nodular goiter patients were enrolled in this study. We evaluated the size, cystic percentage, solid echogenicity, calcification, vascularity, and CEUS parameters for each nodule. The final diagnosis of all patients was confirmed via surgery. Univariate analysis demonstrated that compared with benign nodular goiters, PCPTCs more frequently presented with calcification, hypoechogenicity of the solid part, hypoenhancement, heterogeneous enhancement, centrifugal perfusion, peak intensity index <1, time to peak index ≥1, and area under the curve index <1 on preoperative US and CEUS. Binary logistic regression analysis demonstrated that heterogeneous enhancement, centrifugal perfusion, and peak intensity index <1 are independent CEUS characteristics related to malignant PCPTCs and can be used for their differentiation from benign nodular goiters (all p < 0.05). Our study indicated that preoperative CEUS characteristics may serve as a useful tool to distinguish malignant PCPTCs from benign thyroid nodules.https://www.frontiersin.org/articles/10.3389/fendo.2021.783670/fullthyroid carcinomaspartially cystic thyroid nodulesthyroid ultrasonographypartially cystic papillary thyroid carcinomas (PCPTCs)contrast-enhanced ultrasound (CEUS) |
| spellingShingle | Fengkai Fang Yi Gong Liyan Liao Fei Ye Zhongkun Zuo Zhang Qi Xiaodu Li Chengcheng Niu Value of Contrast-Enhanced Ultrasound in Partially Cystic Papillary Thyroid Carcinomas Frontiers in Endocrinology thyroid carcinomas partially cystic thyroid nodules thyroid ultrasonography partially cystic papillary thyroid carcinomas (PCPTCs) contrast-enhanced ultrasound (CEUS) |
| title | Value of Contrast-Enhanced Ultrasound in Partially Cystic Papillary Thyroid Carcinomas |
| title_full | Value of Contrast-Enhanced Ultrasound in Partially Cystic Papillary Thyroid Carcinomas |
| title_fullStr | Value of Contrast-Enhanced Ultrasound in Partially Cystic Papillary Thyroid Carcinomas |
| title_full_unstemmed | Value of Contrast-Enhanced Ultrasound in Partially Cystic Papillary Thyroid Carcinomas |
| title_short | Value of Contrast-Enhanced Ultrasound in Partially Cystic Papillary Thyroid Carcinomas |
| title_sort | value of contrast enhanced ultrasound in partially cystic papillary thyroid carcinomas |
| topic | thyroid carcinomas partially cystic thyroid nodules thyroid ultrasonography partially cystic papillary thyroid carcinomas (PCPTCs) contrast-enhanced ultrasound (CEUS) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.783670/full |
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