Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies
PurposeRecent scientific reports have revealed a close association between ferroptosis and the occurrence and development of osteoarthritis (OA). Nevertheless, the precise mechanisms by which ferroptosis influences OA and how to hobble OA progression by inhibiting chondrocyte ferroptosis have not ye...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1202436/full |
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| author | Siyang Cao Siyang Cao Siyang Cao Yihao Wei Yihao Wei Yihao Wei Huihui Xu Huihui Xu Huihui Xu Jian Weng Jian Weng Jian Weng Tiantian Qi Tiantian Qi Tiantian Qi Fei Yu Fei Yu Fei Yu Su Liu Su Liu Su Liu Ao Xiong Ao Xiong Ao Xiong Peng Liu Peng Liu Peng Liu Hui Zeng Hui Zeng Hui Zeng |
| author_facet | Siyang Cao Siyang Cao Siyang Cao Yihao Wei Yihao Wei Yihao Wei Huihui Xu Huihui Xu Huihui Xu Jian Weng Jian Weng Jian Weng Tiantian Qi Tiantian Qi Tiantian Qi Fei Yu Fei Yu Fei Yu Su Liu Su Liu Su Liu Ao Xiong Ao Xiong Ao Xiong Peng Liu Peng Liu Peng Liu Hui Zeng Hui Zeng Hui Zeng |
| author_sort | Siyang Cao |
| collection | DOAJ |
| description | PurposeRecent scientific reports have revealed a close association between ferroptosis and the occurrence and development of osteoarthritis (OA). Nevertheless, the precise mechanisms by which ferroptosis influences OA and how to hobble OA progression by inhibiting chondrocyte ferroptosis have not yet been fully elucidated. This study aims to conduct a comprehensive systematic review (SR) to address these gaps.MethodsFollowing the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020, we conducted a comprehensive search of the Embase, Ovid, ProQuest, PubMed, Scopus, the Cochrane Library, and Web of Science databases to identify relevant studies that investigate the association between ferroptosis and chondrocytes in OA. Our search included studies published from the inception of these databases until January 31st, 2023. Only studies that met the predetermined quality criteria were included in this SR.ResultsIn this comprehensive SR, a total of 21 studies that met the specified criteria were considered suitable and included in the current updated synthesis. The mechanisms underlying chondrocyte ferroptosis and its association with OA progression involve various biological phenomena, including mitochondrial dysfunction, dysregulated iron metabolism, oxidative stress, and crucial signaling pathways.ConclusionFerroptosis in chondrocytes has opened an entirely new chapter for the investigation of OA, and targeted regulation of it is springing up as an attractive and promising therapeutic tactic for OA.Systematic review registrationhttps://inplasy.com/inplasy-2023-3-0044/, identifier INPLASY202330044. |
| first_indexed | 2024-03-12T23:38:21Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T23:38:21Z |
| publishDate | 2023-07-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-06e7b5375bff4f2ca768cfcfc356eac92023-07-15T02:55:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.12024361202436Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studiesSiyang Cao0Siyang Cao1Siyang Cao2Yihao Wei3Yihao Wei4Yihao Wei5Huihui Xu6Huihui Xu7Huihui Xu8Jian Weng9Jian Weng10Jian Weng11Tiantian Qi12Tiantian Qi13Tiantian Qi14Fei Yu15Fei Yu16Fei Yu17Su Liu18Su Liu19Su Liu20Ao Xiong21Ao Xiong22Ao Xiong23Peng Liu24Peng Liu25Peng Liu26Hui Zeng27Hui Zeng28Hui Zeng29Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaNational & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Peking University Shenzhen Hospital, Shenzhen, Guangdong, ChinaPurposeRecent scientific reports have revealed a close association between ferroptosis and the occurrence and development of osteoarthritis (OA). Nevertheless, the precise mechanisms by which ferroptosis influences OA and how to hobble OA progression by inhibiting chondrocyte ferroptosis have not yet been fully elucidated. This study aims to conduct a comprehensive systematic review (SR) to address these gaps.MethodsFollowing the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020, we conducted a comprehensive search of the Embase, Ovid, ProQuest, PubMed, Scopus, the Cochrane Library, and Web of Science databases to identify relevant studies that investigate the association between ferroptosis and chondrocytes in OA. Our search included studies published from the inception of these databases until January 31st, 2023. Only studies that met the predetermined quality criteria were included in this SR.ResultsIn this comprehensive SR, a total of 21 studies that met the specified criteria were considered suitable and included in the current updated synthesis. The mechanisms underlying chondrocyte ferroptosis and its association with OA progression involve various biological phenomena, including mitochondrial dysfunction, dysregulated iron metabolism, oxidative stress, and crucial signaling pathways.ConclusionFerroptosis in chondrocytes has opened an entirely new chapter for the investigation of OA, and targeted regulation of it is springing up as an attractive and promising therapeutic tactic for OA.Systematic review registrationhttps://inplasy.com/inplasy-2023-3-0044/, identifier INPLASY202330044.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1202436/fullferroptosischondrocytesosteoarthritiscrosstalksystematic review |
| spellingShingle | Siyang Cao Siyang Cao Siyang Cao Yihao Wei Yihao Wei Yihao Wei Huihui Xu Huihui Xu Huihui Xu Jian Weng Jian Weng Jian Weng Tiantian Qi Tiantian Qi Tiantian Qi Fei Yu Fei Yu Fei Yu Su Liu Su Liu Su Liu Ao Xiong Ao Xiong Ao Xiong Peng Liu Peng Liu Peng Liu Hui Zeng Hui Zeng Hui Zeng Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies Frontiers in Immunology ferroptosis chondrocytes osteoarthritis crosstalk systematic review |
| title | Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies |
| title_full | Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies |
| title_fullStr | Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies |
| title_full_unstemmed | Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies |
| title_short | Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies |
| title_sort | crosstalk between ferroptosis and chondrocytes in osteoarthritis a systematic review of in vivo and in vitro studies |
| topic | ferroptosis chondrocytes osteoarthritis crosstalk systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1202436/full |
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