The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.

BACKGROUND AND OBJECTIVES: It has become increasingly clear that ATM (ataxia-telangiectasia-mutated) safeguards genome stability, which is a cornerstone of cellular homeostasis, and ATM IVS 22-77 T>C affects the normal activity of ATM proteins. However, the association between the ATM IVS 22-77 T...

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Main Authors: Lin Zhao, Aihua Gu, Guixiang Ji, Peng Zou, Peng Zhao, Ailin Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3261868?pdf=render
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author Lin Zhao
Aihua Gu
Guixiang Ji
Peng Zou
Peng Zhao
Ailin Lu
author_facet Lin Zhao
Aihua Gu
Guixiang Ji
Peng Zou
Peng Zhao
Ailin Lu
author_sort Lin Zhao
collection DOAJ
description BACKGROUND AND OBJECTIVES: It has become increasingly clear that ATM (ataxia-telangiectasia-mutated) safeguards genome stability, which is a cornerstone of cellular homeostasis, and ATM IVS 22-77 T>C affects the normal activity of ATM proteins. However, the association between the ATM IVS 22-77 T>C genetic variant and cancer risk is controversial. Therefore, we conducted a systematic meta-analysis to estimate the overall cancer risk associated with the polymorphism and to quantify any potential between-study heterogeneity. METHODS: A total of nine studies including 4,470 cases and 4,862 controls were analyzed for ATM IVS 22-77 T>C association with cancer risk in this meta-analysis. Heterogeneity among articles and their publication bias were also tested. RESULTS: Our results showed that no association reached the level of statistical significance in the overall risk. Interestingly, in the stratified analyses, we observed an inverse relationship in lung and breast cancer. CONCLUSION: Further functional research on the ATM mechanism should be performed to explain the inconsistent results in different cancer types.
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spelling doaj.art-06e7b7255f0a4755972d6728494e6bfe2022-12-22T00:13:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0171e2947910.1371/journal.pone.0029479The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.Lin ZhaoAihua GuGuixiang JiPeng ZouPeng ZhaoAilin LuBACKGROUND AND OBJECTIVES: It has become increasingly clear that ATM (ataxia-telangiectasia-mutated) safeguards genome stability, which is a cornerstone of cellular homeostasis, and ATM IVS 22-77 T>C affects the normal activity of ATM proteins. However, the association between the ATM IVS 22-77 T>C genetic variant and cancer risk is controversial. Therefore, we conducted a systematic meta-analysis to estimate the overall cancer risk associated with the polymorphism and to quantify any potential between-study heterogeneity. METHODS: A total of nine studies including 4,470 cases and 4,862 controls were analyzed for ATM IVS 22-77 T>C association with cancer risk in this meta-analysis. Heterogeneity among articles and their publication bias were also tested. RESULTS: Our results showed that no association reached the level of statistical significance in the overall risk. Interestingly, in the stratified analyses, we observed an inverse relationship in lung and breast cancer. CONCLUSION: Further functional research on the ATM mechanism should be performed to explain the inconsistent results in different cancer types.http://europepmc.org/articles/PMC3261868?pdf=render
spellingShingle Lin Zhao
Aihua Gu
Guixiang Ji
Peng Zou
Peng Zhao
Ailin Lu
The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.
PLoS ONE
title The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.
title_full The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.
title_fullStr The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.
title_full_unstemmed The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.
title_short The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.
title_sort association between atm ivs 22 77 t c and cancer risk a meta analysis
url http://europepmc.org/articles/PMC3261868?pdf=render
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