Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
One of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms of action that favor cell survival and proliferation, becoming one of the leading causes of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1287505/full |
| _version_ | 1797629468049670144 |
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| author | Sandra Cotino-Nájera Luis A. Herrera Luis A. Herrera Guadalupe Domínguez-Gómez José Díaz-Chávez |
| author_facet | Sandra Cotino-Nájera Luis A. Herrera Luis A. Herrera Guadalupe Domínguez-Gómez José Díaz-Chávez |
| author_sort | Sandra Cotino-Nájera |
| collection | DOAJ |
| description | One of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms of action that favor cell survival and proliferation, becoming one of the leading causes of treatment failure against cancer. A promising strategy to overcome chemoresistance and radioresistance is the co-administration of anticancer agents and natural compounds with anticancer properties, such as the polyphenolic compound resveratrol (RSV). RSV has been reported to be able to sensitize cancer cells to chemotherapeutic agents and radiotherapy, promoting cancer cell death. This review describes the reported molecular mechanisms by which RSV sensitizes tumor cells to radiotherapy and chemotherapy treatment. |
| first_indexed | 2024-03-11T10:54:52Z |
| format | Article |
| id | doaj.art-06e8fa0b0b3645578428d78efedfd953 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T10:54:52Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-06e8fa0b0b3645578428d78efedfd9532023-11-13T10:39:11ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.12875051287505Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancerSandra Cotino-Nájera0Luis A. Herrera1Luis A. Herrera2Guadalupe Domínguez-Gómez3José Díaz-Chávez4Laboratorio de Oncología Molecular, Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de México, MexicoLaboratorio de Oncología Molecular, Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de México, MexicoEscuela de Medicina y Ciencias de la Salud-Tecnológico de Monterrey, México City, MexicoSubdirección de Investigación Clínica, Instituto Nacional de Cancerología (INCAN), Ciudad de México, MexicoUnidad de Investigación en Cáncer, Instituto de Investigaciones Biomédicas-Universidad Nacional Autónoma de México, Instituto Nacional de Cancerología, Ciudad de México, MexicoOne of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms of action that favor cell survival and proliferation, becoming one of the leading causes of treatment failure against cancer. A promising strategy to overcome chemoresistance and radioresistance is the co-administration of anticancer agents and natural compounds with anticancer properties, such as the polyphenolic compound resveratrol (RSV). RSV has been reported to be able to sensitize cancer cells to chemotherapeutic agents and radiotherapy, promoting cancer cell death. This review describes the reported molecular mechanisms by which RSV sensitizes tumor cells to radiotherapy and chemotherapy treatment.https://www.frontiersin.org/articles/10.3389/fphar.2023.1287505/fullradioresistancechemoresistanceresveratrolcancermolecular mechanisms |
| spellingShingle | Sandra Cotino-Nájera Luis A. Herrera Luis A. Herrera Guadalupe Domínguez-Gómez José Díaz-Chávez Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer Frontiers in Pharmacology radioresistance chemoresistance resveratrol cancer molecular mechanisms |
| title | Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer |
| title_full | Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer |
| title_fullStr | Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer |
| title_full_unstemmed | Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer |
| title_short | Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer |
| title_sort | molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer |
| topic | radioresistance chemoresistance resveratrol cancer molecular mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1287505/full |
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