Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs
Background/Aim. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47) 7.62 mm, after the primary surgical management, were closed with delayed primary suture during the next four to seven days. This period coincides with the fibroblastic phase of wound healing. Fibrin glue is used as...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defance, Serbia
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500050D.pdf |
| _version_ | 1818320311863476224 |
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| author | Đenić Nebojša Višnjić Milan Dragović Saša Bojanić Vladmila Bojanić Zoran Đurđević Dragan Đinđić Boris Kostov Miloš |
| author_facet | Đenić Nebojša Višnjić Milan Dragović Saša Bojanić Vladmila Bojanić Zoran Đurđević Dragan Đinđić Boris Kostov Miloš |
| author_sort | Đenić Nebojša |
| collection | DOAJ |
| description | Background/Aim. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47)
7.62 mm, after the primary surgical management, were closed with delayed
primary suture during the next four to seven days. This period coincides with
the fibroblastic phase of wound healing. Fibrin glue is used as a local
hemostatic and as a matrix for the local dosed release of antibiotics.
Antibiotics addition to fibrin glue resulted in continuous diffusion into the
surrounding next 4 to 7 days. The aim of this study was to create the
preconditions for gunshot wounds closing without complications by the
application of fibrin glue with antibiotics 24 h after primary surgical
treatment. Methods. A total of 14 pigs were wounded in the gluteofemoral
region by the bullet M67, initial velocity of 720 m/s. All wounded animals
were surgically treated according to the principles of the warsurgery
doctrine. Seven wounds were closed with primary delayed suture four days
after the primary surgical treatment (traditional approach). Fibrin glue with
antibiotics was introduced in seven wounds during the primary surgical
treatment and primary delayed suture was done after 24 h. The macroscopic
appearance and the clinical assessment of the wound were done during the
primary surgical treatment and during its revision after 24 h, as well as
histopathological findings at the days 4 and 7 after wounding. Results.
Gunshot wounds caused by the automatic rifle M70AB2 (AK-47) 7.62 mm, and
treated with fibrin glue with antibiotics after primary surgical management,
were closed with primary delayed suture after 24 h. In further wound
evolution there were no complications. Conclusion. Uncomplicated soft-tissue
wounds caused by an automatic M70AB2 rifle may be closed primarily with
delayed suture without the risk of developing complications if on revision,
24 h after primary surgery, there were no present necrotic tissues, hematoma,
and any signs of infection when fibrin glue with antibiotics (ceftriaxone and
clindamycin) was applied. The use of this method should be limited to
individual and strictly controlled cases in civil practice for now. |
| first_indexed | 2024-12-13T10:23:00Z |
| format | Article |
| id | doaj.art-06e96734db9b4197ba74401e618762b0 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-13T10:23:00Z |
| publishDate | 2015-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-06e96734db9b4197ba74401e618762b02022-12-21T23:51:08ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202015-01-0172978579310.2298/VSP131106050D0042-84501500050DExperimental closure of gunshot wounds by fibrin glue with antibiotics in pigsĐenić Nebojša0Višnjić Milan1Dragović Saša2Bojanić Vladmila3Bojanić Zoran4Đurđević Dragan5Đinđić Boris6Kostov Miloš7Military Hospital, Department of General Surgery, Niš + Faculty of Medicine, NišFaculty of Medicine, NišDepartment of General Surgery, Military Hospital, NišFaculty of Medicine, NišFaculty of Medicine, NišMilitary Medical Academy, Institute for Medical Research, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeFaculty of Medicine, NišMilitary Hospital, Department of General Surgery, Niš + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeBackground/Aim. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47) 7.62 mm, after the primary surgical management, were closed with delayed primary suture during the next four to seven days. This period coincides with the fibroblastic phase of wound healing. Fibrin glue is used as a local hemostatic and as a matrix for the local dosed release of antibiotics. Antibiotics addition to fibrin glue resulted in continuous diffusion into the surrounding next 4 to 7 days. The aim of this study was to create the preconditions for gunshot wounds closing without complications by the application of fibrin glue with antibiotics 24 h after primary surgical treatment. Methods. A total of 14 pigs were wounded in the gluteofemoral region by the bullet M67, initial velocity of 720 m/s. All wounded animals were surgically treated according to the principles of the warsurgery doctrine. Seven wounds were closed with primary delayed suture four days after the primary surgical treatment (traditional approach). Fibrin glue with antibiotics was introduced in seven wounds during the primary surgical treatment and primary delayed suture was done after 24 h. The macroscopic appearance and the clinical assessment of the wound were done during the primary surgical treatment and during its revision after 24 h, as well as histopathological findings at the days 4 and 7 after wounding. Results. Gunshot wounds caused by the automatic rifle M70AB2 (AK-47) 7.62 mm, and treated with fibrin glue with antibiotics after primary surgical management, were closed with primary delayed suture after 24 h. In further wound evolution there were no complications. Conclusion. Uncomplicated soft-tissue wounds caused by an automatic M70AB2 rifle may be closed primarily with delayed suture without the risk of developing complications if on revision, 24 h after primary surgery, there were no present necrotic tissues, hematoma, and any signs of infection when fibrin glue with antibiotics (ceftriaxone and clindamycin) was applied. The use of this method should be limited to individual and strictly controlled cases in civil practice for now.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500050D.pdfwounds, gunshotwound closure techniquesfibrin tissue adhesiveanti-bacterial agentssurgical procedures, operativetreatment outcomeswine |
| spellingShingle | Đenić Nebojša Višnjić Milan Dragović Saša Bojanić Vladmila Bojanić Zoran Đurđević Dragan Đinđić Boris Kostov Miloš Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs Vojnosanitetski Pregled wounds, gunshot wound closure techniques fibrin tissue adhesive anti-bacterial agents surgical procedures, operative treatment outcome swine |
| title | Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs |
| title_full | Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs |
| title_fullStr | Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs |
| title_full_unstemmed | Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs |
| title_short | Experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs |
| title_sort | experimental closure of gunshot wounds by fibrin glue with antibiotics in pigs |
| topic | wounds, gunshot wound closure techniques fibrin tissue adhesive anti-bacterial agents surgical procedures, operative treatment outcome swine |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500050D.pdf |
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