The effects of topical metronidazole on post-hemorrhoidectomy pain: a brief report
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| Language: | fas |
| Published: |
Tehran University of Medical Sciences
2012-01-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-188&slc_lang=en&sid=1 |
| _version_ | 1819126657930231808 |
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| author | Pourghassem J Mahoori A Akhbari P |
| author_facet | Pourghassem J Mahoori A Akhbari P |
| author_sort | Pourghassem J |
| collection | DOAJ |
| description | Normal
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Background: Oral
metronidazole has been previously demonstrated to decrease postoperative pain
after open hemorrhoidectomy. The aim of this study was to evaluate the effect
of topical metronidazole in reducing postoperative pain of hemorrhoidectomy.Methods : In this double-blind, clinical trial forty 20- to 40-year old male patients were scheduled for hemorrhoidectomy under
spinal anesthesia at the Imam Khomeini Hospital in Urmia, Iran from April to
September 2010. The participants were assigned to receive topical metronidazole (n=20) or placebo (n=20). Pain intensity was assessed
using
a visual analog scale (VAS), the time of first narcotic request and morphine administrations were also
recorded. Results : The VAS scores were lower in metronidazole than the control group but this
difference was not statistically significant, except after 24 hr post-surgically. Morphine administration
in the first 24 hr was lower in the metronidazole group (P<0.05).Conclusion: Although metronidazole
could not prolong the time of first analgesic request, but application of
metronidazole gel is associated with lower analgesic requirement. |
| first_indexed | 2024-12-22T07:59:31Z |
| format | Article |
| id | doaj.art-06ea6f79e82b4258a19da548fc8045f7 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-22T07:59:31Z |
| publishDate | 2012-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-06ea6f79e82b4258a19da548fc8045f72022-12-21T18:33:17ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222012-01-016910651655The effects of topical metronidazole on post-hemorrhoidectomy pain: a brief reportPourghassem J0Mahoori A1Akhbari P2 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal" mso-tstyle-rowband-size:0 mso-tstyle-colband-size:0 mso-style-noshow:yes mso-style-priority:99 mso-style-qformat:yes mso-style-parent:"" mso-padding-alt:0cm 5.4pt 0cm 5.4pt mso-para-margin:0cm mso-para-margin-bottom:.0001pt mso-pagination:widow-orphan font-size:11.0pt font-family:"Calibri","sans-serif" mso-ascii-font-family:Calibri mso-ascii-theme-font:minor-latin mso-fareast-font-family:"Times New Roman" mso-fareast-theme-font:minor-fareast mso-hansi-font-family:Calibri mso-hansi-theme-font:minor-latin mso-bidi-font-family:Arial mso-bidi-theme-font:minor-bidi} Background: Oral metronidazole has been previously demonstrated to decrease postoperative pain after open hemorrhoidectomy. The aim of this study was to evaluate the effect of topical metronidazole in reducing postoperative pain of hemorrhoidectomy.Methods : In this double-blind, clinical trial forty 20- to 40-year old male patients were scheduled for hemorrhoidectomy under spinal anesthesia at the Imam Khomeini Hospital in Urmia, Iran from April to September 2010. The participants were assigned to receive topical metronidazole (n=20) or placebo (n=20). Pain intensity was assessed using a visual analog scale (VAS), the time of first narcotic request and morphine administrations were also recorded. Results : The VAS scores were lower in metronidazole than the control group but this difference was not statistically significant, except after 24 hr post-surgically. Morphine administration in the first 24 hr was lower in the metronidazole group (P<0.05).Conclusion: Although metronidazole could not prolong the time of first analgesic request, but application of metronidazole gel is associated with lower analgesic requirement.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-188&slc_lang=en&sid=1Hemorrhoidectomypaintopical metronidazole |
| spellingShingle | Pourghassem J Mahoori A Akhbari P The effects of topical metronidazole on post-hemorrhoidectomy pain: a brief report Tehran University Medical Journal Hemorrhoidectomy pain topical metronidazole |
| title | The effects of topical metronidazole on post-hemorrhoidectomy pain: a brief report |
| title_full | The effects of topical metronidazole on post-hemorrhoidectomy pain: a brief report |
| title_fullStr | The effects of topical metronidazole on post-hemorrhoidectomy pain: a brief report |
| title_full_unstemmed | The effects of topical metronidazole on post-hemorrhoidectomy pain: a brief report |
| title_short | The effects of topical metronidazole on post-hemorrhoidectomy pain: a brief report |
| title_sort | effects of topical metronidazole on post hemorrhoidectomy pain a brief report |
| topic | Hemorrhoidectomy pain topical metronidazole |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-188&slc_lang=en&sid=1 |
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