Acute Liver Failure Induces Glial Reactivity, Oxidative Stress and Impairs Brain Energy Metabolism in Rats

Acute Liver Failure Induces Glial Reactivity, Oxidative Stress and Impairs Brain Energy Metabolism in Rats

Acute liver failure (ALF) implies a severe and rapid liver dysfunction that leads to impaired liver metabolism and hepatic encephalopathy (HE). Recent studies have suggested that several brain alterations such as astrocytic dysfunction and energy metabolism impairment may synergistically interact, p...

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Bibliographic Details
Main Authors: Pedro Arend Guazzelli, Giordano Fabricio Cittolin-Santos, Leo Anderson Meira-Martins, Mateus Grings, Yasmine Nonose, Gabriel S. Lazzarotto, Daniela Nogara, Jussemara S. da Silva, Fernanda U. Fontella, Moacir Wajner, Guilhian Leipnitz, Diogo O. Souza, Adriano Martimbianco de Assis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
acute liver failure
brain energy metabolism
hepatic encephalopathy
redox homeostasis
mitochondria
glial reactivity
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00327/full

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