Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Sarcopenic obesity and diabetes are two increasing health problems worldwide, which both share many common risk factors, such as aging, and general obesity. The pathogenesis of sarcopenic obesity includes aging, physical inactivity, malnutrition, low-grade inflammation, insulin resistance, and hormo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00568/full |
| _version_ | 1818341852433088512 |
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| author | Mina Wang Mina Wang Yan Tan Yifan Shi Xu Wang Zehuan Liao Zehuan Liao Peng Wei |
| author_facet | Mina Wang Mina Wang Yan Tan Yifan Shi Xu Wang Zehuan Liao Zehuan Liao Peng Wei |
| author_sort | Mina Wang |
| collection | DOAJ |
| description | Sarcopenic obesity and diabetes are two increasing health problems worldwide, which both share many common risk factors, such as aging, and general obesity. The pathogenesis of sarcopenic obesity includes aging, physical inactivity, malnutrition, low-grade inflammation, insulin resistance, and hormonal changes. Nevertheless, there are two major reasons to cause diabetes: impaired insulin secretion and impaired insulin action. Furthermore, the individual diagnosis of obesity and sarcopenia should be combined to adequately define sarcopenic obesity. Also, the diagnosis of diabetes includes fasting plasma glucose test (FPG), 2-h oral glucose tolerance test (OGTT), glycated hemoglobin (A1C), and random plasma glucose coupled with symptoms. Healthy diet and physical activity are beneficial to both sarcopenic obesity and diabetes, but there are only recommended drugs for diabetes. This review consolidates and discusses the latest research in pathogenesis, diagnosis, and treatments of diabetes and sarcopenic obesity. |
| first_indexed | 2024-12-13T16:05:23Z |
| format | Article |
| id | doaj.art-06eb3d0b0fc34a7a92b7bd0c354578d8 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T16:05:23Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-06eb3d0b0fc34a7a92b7bd0c354578d82022-12-21T23:39:04ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-08-011110.3389/fendo.2020.00568553369Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and TreatmentsMina Wang0Mina Wang1Yan Tan2Yifan Shi3Xu Wang4Zehuan Liao5Zehuan Liao6Peng Wei7School of Traditional Chinese Medicine, School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaBeijing Key Laboratory of Acupuncture Neuromodulation, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaSchool of Traditional Chinese Medicine, School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Biological Sciences, Nanyang Technological University, Singapore, SingaporeDepartment of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Biomedicum, Stockholm, SwedenSchool of Traditional Chinese Medicine, School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSarcopenic obesity and diabetes are two increasing health problems worldwide, which both share many common risk factors, such as aging, and general obesity. The pathogenesis of sarcopenic obesity includes aging, physical inactivity, malnutrition, low-grade inflammation, insulin resistance, and hormonal changes. Nevertheless, there are two major reasons to cause diabetes: impaired insulin secretion and impaired insulin action. Furthermore, the individual diagnosis of obesity and sarcopenia should be combined to adequately define sarcopenic obesity. Also, the diagnosis of diabetes includes fasting plasma glucose test (FPG), 2-h oral glucose tolerance test (OGTT), glycated hemoglobin (A1C), and random plasma glucose coupled with symptoms. Healthy diet and physical activity are beneficial to both sarcopenic obesity and diabetes, but there are only recommended drugs for diabetes. This review consolidates and discusses the latest research in pathogenesis, diagnosis, and treatments of diabetes and sarcopenic obesity.https://www.frontiersin.org/article/10.3389/fendo.2020.00568/fulldiabetessarcopenic obesityinsulin resistanceaginginflammation |
| spellingShingle | Mina Wang Mina Wang Yan Tan Yifan Shi Xu Wang Zehuan Liao Zehuan Liao Peng Wei Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments Frontiers in Endocrinology diabetes sarcopenic obesity insulin resistance aging inflammation |
| title | Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments |
| title_full | Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments |
| title_fullStr | Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments |
| title_full_unstemmed | Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments |
| title_short | Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments |
| title_sort | diabetes and sarcopenic obesity pathogenesis diagnosis and treatments |
| topic | diabetes sarcopenic obesity insulin resistance aging inflammation |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00568/full |
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