The potential therapeutic role of extracellular vesicles in osteoarthritis
Osteoarthritis (OA) is a worldwide and disabling disease, which cause severe pain and heavy socioeconomic burden. However, pharmacologic or surgical therapies cannot mitigate OA progression. Mesenchymal stem cells (MSCs) therapy has emerged as potential approach for OA treatment, while the immunogen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1022368/full |
| _version_ | 1828404165065310208 |
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| author | Yu Zhuang Yu Zhuang Yu Zhuang Shengjie Jiang Shengjie Jiang Shengjie Jiang Changyong Yuan Changyong Yuan Changyong Yuan Kaili Lin Kaili Lin Kaili Lin |
| author_facet | Yu Zhuang Yu Zhuang Yu Zhuang Shengjie Jiang Shengjie Jiang Shengjie Jiang Changyong Yuan Changyong Yuan Changyong Yuan Kaili Lin Kaili Lin Kaili Lin |
| author_sort | Yu Zhuang |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a worldwide and disabling disease, which cause severe pain and heavy socioeconomic burden. However, pharmacologic or surgical therapies cannot mitigate OA progression. Mesenchymal stem cells (MSCs) therapy has emerged as potential approach for OA treatment, while the immunogenicity and ethical audit of cell therapy are unavoidable. Compared with stem cell strategy, EVs induce less immunological rejection, and they are more stable for storage and in vivo application. MSC-EVs-based therapy possesses great potential in regulating inflammation and promoting cartilage matrix reconstruction in OA treatment. To enhance the therapeutic effect, delivery efficiency, tissue specificity and safety, EVs can be engineered via different modification strategies. Here, the application of MSC-EVs in OA treatment and the potential underlying mechanism were summarized. Moreover, EV modification strategies including indirect MSC modification and direct EV modification were reviewed. |
| first_indexed | 2024-12-10T10:31:48Z |
| format | Article |
| id | doaj.art-06eb5d410b7944b8998c336350c0bbaa |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T10:31:48Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-06eb5d410b7944b8998c336350c0bbaa2022-12-22T01:52:32ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.10223681022368The potential therapeutic role of extracellular vesicles in osteoarthritisYu Zhuang0Yu Zhuang1Yu Zhuang2Shengjie Jiang3Shengjie Jiang4Shengjie Jiang5Changyong Yuan6Changyong Yuan7Changyong Yuan8Kaili Lin9Kaili Lin10Kaili Lin11Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, ChinaDepartment of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, ChinaSchool of Stomatology, Xuzhou Medical University, Shanghai, ChinaDepartment of Dental Implant, The Affiliated Stomatological Hospital of Xuzhou Medical University, Shanghai, ChinaShanghai Key Laboratory of Stomatology, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollege of Stomatology, Shanghai Jiao Tong University, Shanghai, ChinaNational Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, ChinaOsteoarthritis (OA) is a worldwide and disabling disease, which cause severe pain and heavy socioeconomic burden. However, pharmacologic or surgical therapies cannot mitigate OA progression. Mesenchymal stem cells (MSCs) therapy has emerged as potential approach for OA treatment, while the immunogenicity and ethical audit of cell therapy are unavoidable. Compared with stem cell strategy, EVs induce less immunological rejection, and they are more stable for storage and in vivo application. MSC-EVs-based therapy possesses great potential in regulating inflammation and promoting cartilage matrix reconstruction in OA treatment. To enhance the therapeutic effect, delivery efficiency, tissue specificity and safety, EVs can be engineered via different modification strategies. Here, the application of MSC-EVs in OA treatment and the potential underlying mechanism were summarized. Moreover, EV modification strategies including indirect MSC modification and direct EV modification were reviewed.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1022368/fullextracellular vesiclesosteoarthritismesenchymal stem cellstherapeutic treatmentEV engineering |
| spellingShingle | Yu Zhuang Yu Zhuang Yu Zhuang Shengjie Jiang Shengjie Jiang Shengjie Jiang Changyong Yuan Changyong Yuan Changyong Yuan Kaili Lin Kaili Lin Kaili Lin The potential therapeutic role of extracellular vesicles in osteoarthritis Frontiers in Bioengineering and Biotechnology extracellular vesicles osteoarthritis mesenchymal stem cells therapeutic treatment EV engineering |
| title | The potential therapeutic role of extracellular vesicles in osteoarthritis |
| title_full | The potential therapeutic role of extracellular vesicles in osteoarthritis |
| title_fullStr | The potential therapeutic role of extracellular vesicles in osteoarthritis |
| title_full_unstemmed | The potential therapeutic role of extracellular vesicles in osteoarthritis |
| title_short | The potential therapeutic role of extracellular vesicles in osteoarthritis |
| title_sort | potential therapeutic role of extracellular vesicles in osteoarthritis |
| topic | extracellular vesicles osteoarthritis mesenchymal stem cells therapeutic treatment EV engineering |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1022368/full |
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