Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer.
Inhibitors of apoptosis proteins (IAPs) have been well investigated in human cancers, where they are frequently overexpressed and associated with poor prognosis. Here we explored the role of baculoviral IAP repeat containing 6 (BIRC6), a member of IAPs, in human colorectal cancer (CRC).We used Weste...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4416929?pdf=render |
| _version_ | 1818943722108223488 |
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| author | Tingting Hu Shuqiang Weng Wenqing Tang Ruyi Xue She Chen Guoxiang Cai Yu Cai Xizhong Shen Si Zhang Ling Dong |
| author_facet | Tingting Hu Shuqiang Weng Wenqing Tang Ruyi Xue She Chen Guoxiang Cai Yu Cai Xizhong Shen Si Zhang Ling Dong |
| author_sort | Tingting Hu |
| collection | DOAJ |
| description | Inhibitors of apoptosis proteins (IAPs) have been well investigated in human cancers, where they are frequently overexpressed and associated with poor prognosis. Here we explored the role of baculoviral IAP repeat containing 6 (BIRC6), a member of IAPs, in human colorectal cancer (CRC).We used Western blotting and immunohistochemistry to examine BIRC6 expression in 7 CRC cell lines and 126 CRC clinical samples. We determined the biological significance of BIRC6 in CRC cell lines by a lentivirus-mediated silencing method.We reported that BIRC6 was overexpressed in CRC cell lines and clinical CRC tissues. BIRC6 overexpression was correlated with tumor size and invasion depth of CRC. BIRC6 overexpression is associated with worse overall survival (OS) (P = 0.001) and shorter disease-free survival (DFS) (P = 0.010). BIRC6 knockdown inhibited cell proliferation, arrested cell cycle at S phase, downregulated cyclin A2, B1, D1 and E1 levels, and sensitized CRC cells to chemotherapy in vitro and in vivo.Taken together, these data suggests that BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and BIRC6 could be a potential target of CRC therapy. |
| first_indexed | 2024-12-20T07:31:50Z |
| format | Article |
| id | doaj.art-06ecb33ddaad4fff85a74584e7b9e221 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T07:31:50Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-06ecb33ddaad4fff85a74584e7b9e2212022-12-21T19:48:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012528110.1371/journal.pone.0125281Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer.Tingting HuShuqiang WengWenqing TangRuyi XueShe ChenGuoxiang CaiYu CaiXizhong ShenSi ZhangLing DongInhibitors of apoptosis proteins (IAPs) have been well investigated in human cancers, where they are frequently overexpressed and associated with poor prognosis. Here we explored the role of baculoviral IAP repeat containing 6 (BIRC6), a member of IAPs, in human colorectal cancer (CRC).We used Western blotting and immunohistochemistry to examine BIRC6 expression in 7 CRC cell lines and 126 CRC clinical samples. We determined the biological significance of BIRC6 in CRC cell lines by a lentivirus-mediated silencing method.We reported that BIRC6 was overexpressed in CRC cell lines and clinical CRC tissues. BIRC6 overexpression was correlated with tumor size and invasion depth of CRC. BIRC6 overexpression is associated with worse overall survival (OS) (P = 0.001) and shorter disease-free survival (DFS) (P = 0.010). BIRC6 knockdown inhibited cell proliferation, arrested cell cycle at S phase, downregulated cyclin A2, B1, D1 and E1 levels, and sensitized CRC cells to chemotherapy in vitro and in vivo.Taken together, these data suggests that BIRC6 overexpression is a predictor of poor prognosis in colorectal cancer and BIRC6 could be a potential target of CRC therapy.http://europepmc.org/articles/PMC4416929?pdf=render |
| spellingShingle | Tingting Hu Shuqiang Weng Wenqing Tang Ruyi Xue She Chen Guoxiang Cai Yu Cai Xizhong Shen Si Zhang Ling Dong Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer. PLoS ONE |
| title | Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer. |
| title_full | Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer. |
| title_fullStr | Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer. |
| title_full_unstemmed | Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer. |
| title_short | Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer. |
| title_sort | overexpression of birc6 is a predictor of prognosis for colorectal cancer |
| url | http://europepmc.org/articles/PMC4416929?pdf=render |
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