Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China
The substantial increase in prevalence and emergence of antigenically divergent or highly pathogenic influenza A(H7N9) viruses during 2016–17 raises concerns about the epizootic potential of these viruses. We investigated the evolution and adaptation of H7N9 viruses by analyzing available data and n...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2018-10-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/24/10/17-1063_article |
| _version_ | 1818551700770783232 |
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| author | Jing Lu Jayna Raghwani Rhys Pryce Thomas A. Bowden Julien Thézé Shanqian Huang Yingchao Song Lirong Zou Lijun Liang Ru Bai Yi Jing Pingping Zhou Min Kang Lina Yi Jie Wu Oliver G. Pybus Changwen Ke |
| author_facet | Jing Lu Jayna Raghwani Rhys Pryce Thomas A. Bowden Julien Thézé Shanqian Huang Yingchao Song Lirong Zou Lijun Liang Ru Bai Yi Jing Pingping Zhou Min Kang Lina Yi Jie Wu Oliver G. Pybus Changwen Ke |
| author_sort | Jing Lu |
| collection | DOAJ |
| description | The substantial increase in prevalence and emergence of antigenically divergent or highly pathogenic influenza A(H7N9) viruses during 2016–17 raises concerns about the epizootic potential of these viruses. We investigated the evolution and adaptation of H7N9 viruses by analyzing available data and newly generated virus sequences isolated in Guangdong Province, China, during 2015–2017. Phylogenetic analyses showed that circulating H7N9 viruses belong to distinct lineages with differing spatial distributions. Hemagglutination inhibition assays performed on serum samples from patients infected with these viruses identified 3 antigenic clusters for 16 strains of different virus lineages. We used ancestral sequence reconstruction to identify parallel amino acid changes on multiple separate lineages. We inferred that mutations in hemagglutinin occur primarily at sites involved in receptor recognition or antigenicity. Our results indicate that highly pathogenic strains likely emerged from viruses circulating in eastern Guangdong Province during March 2016 and are associated with a high rate of adaptive molecular evolution. |
| first_indexed | 2024-12-12T09:03:23Z |
| format | Article |
| id | doaj.art-06ef8630c504447aaa8d1732dd20f345 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T09:03:23Z |
| publishDate | 2018-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-06ef8630c504447aaa8d1732dd20f3452022-12-22T00:29:44ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-10-0124101795180510.3201/eid2410.171063Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in ChinaJing LuJayna RaghwaniRhys PryceThomas A. BowdenJulien ThézéShanqian HuangYingchao SongLirong ZouLijun LiangRu BaiYi JingPingping ZhouMin KangLina YiJie WuOliver G. PybusChangwen KeThe substantial increase in prevalence and emergence of antigenically divergent or highly pathogenic influenza A(H7N9) viruses during 2016–17 raises concerns about the epizootic potential of these viruses. We investigated the evolution and adaptation of H7N9 viruses by analyzing available data and newly generated virus sequences isolated in Guangdong Province, China, during 2015–2017. Phylogenetic analyses showed that circulating H7N9 viruses belong to distinct lineages with differing spatial distributions. Hemagglutination inhibition assays performed on serum samples from patients infected with these viruses identified 3 antigenic clusters for 16 strains of different virus lineages. We used ancestral sequence reconstruction to identify parallel amino acid changes on multiple separate lineages. We inferred that mutations in hemagglutinin occur primarily at sites involved in receptor recognition or antigenicity. Our results indicate that highly pathogenic strains likely emerged from viruses circulating in eastern Guangdong Province during March 2016 and are associated with a high rate of adaptive molecular evolution.https://wwwnc.cdc.gov/eid/article/24/10/17-1063_articleavian influenzaavian influenza virusvirusesinfluenzaH7N9phylogenetics |
| spellingShingle | Jing Lu Jayna Raghwani Rhys Pryce Thomas A. Bowden Julien Thézé Shanqian Huang Yingchao Song Lirong Zou Lijun Liang Ru Bai Yi Jing Pingping Zhou Min Kang Lina Yi Jie Wu Oliver G. Pybus Changwen Ke Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China Emerging Infectious Diseases avian influenza avian influenza virus viruses influenza H7N9 phylogenetics |
| title | Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China |
| title_full | Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China |
| title_fullStr | Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China |
| title_full_unstemmed | Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China |
| title_short | Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China |
| title_sort | molecular evolution diversity and adaptation of influenza a h7n9 viruses in china |
| topic | avian influenza avian influenza virus viruses influenza H7N9 phylogenetics |
| url | https://wwwnc.cdc.gov/eid/article/24/10/17-1063_article |
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