Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings
Abstarct. The aim of the present investigation was to evaluate the effects of aflatoxin B1 and Mycotox NG applied either independently or together, on blood total protein, albumin, blood glucose, total bilirubin, triglycerides, cholesterol, enzyme activities of alanine aminotransferase (ALT), as...
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| Format: | Article |
| Language: | English |
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Trakia University. Faculty of Agriculture, Stara Zagora
2020-09-01
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| Series: | Agricultural Science and Technology |
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| Online Access: | https://agriscitech.eu/complex-toxin-binder-mycotox-ng-influence-on-the-hepatotoxic-effect-of-aflatoxin-b1-in-experimental-treated-goslings/ |
| _version_ | 1818321346265874432 |
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| author | I. Valchev К. Stojanchev N. Nicolov R. Binev |
| author_facet | I. Valchev К. Stojanchev N. Nicolov R. Binev |
| author_sort | I. Valchev |
| collection | DOAJ |
| description | Abstarct. The aim of the present investigation was to evaluate the effects of aflatoxin B1
and Mycotox NG applied either independently or
together, on blood total protein, albumin, blood glucose, total bilirubin, triglycerides, cholesterol, enzyme activities of alanine aminotransferase
(ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), gamma-glutamyl transferase (γ GT), lactate dehydrogenase (LDH) and
changes in liver morphology. At the same time, the potential of supplementation of feed with a mycosorbent (Mycotox NG) was evaluated.
Experiments were carried out with 40 1-day-old Toulouse geese from mixed sexes divided into one control and three treatment groups (n=10).
Groups were as followed: Group I – control (0 mg/kg AFB1
not supplemented with Mycotox NG); Group II (0.5 g/kg Mycotox NG), Group III (0.5
mg/kg AFB1
) and Group IV (0.5 mg/kg AFB1 and 0.5 g/kg Mycotox NG). In this study, commercially available geese of Toulouse strain were
reared from day one to forty two days in the deep litter system of management and the birds were divided into four groups. Normal feed tested
free of aflatoxin (AFB1
), was given to the control (Group - 1). 0.5 g/kg Mycotox was supplemented with the feed to Group 2, Aflatoxin (0.5 mg/
kg feed) was supplemented with the feed to Group 3 and Mycotox Ng (0.5 g/kg feed) + 0.5 mg/kg feed AFB1
was supplemented with the feed
to Group 4. The duration of the experiments was 42 days. The monitored blood chemical parameters were analysed on post treatment days 21
and 42. In birds treated only with AFB1, (group III) increased blood activities of studied enzymes. At the same time, blood total protein, albumin,
cholesterol, glucose and triglycerides were reduced as compared to controls. The observed histopathological changes in the liver consisted in
various extent of dystrophy (congestion, vacuolar and granular dystrophy, round cell proliferation, necrobiotic changes, hyperplasia of gallbladder epithelium). The addition of mycosorbent (Mycotox NG) to the feed of Groups IV reduced substantially the changes in blood chemistry and
the severity and frequency of liver histological lesions. The addition of mycosorbent (Mycotox NG) to the feed of Groups IV reduced substantially the changes in blood chemistry and the severity and frequency of liver histological lesions. |
| first_indexed | 2024-12-13T10:39:26Z |
| format | Article |
| id | doaj.art-06efba30bfe644788d84721e5f6c6900 |
| institution | Directory Open Access Journal |
| issn | 1313-8820 1314-412X |
| language | English |
| last_indexed | 2024-12-13T10:39:26Z |
| publishDate | 2020-09-01 |
| publisher | Trakia University. Faculty of Agriculture, Stara Zagora |
| record_format | Article |
| series | Agricultural Science and Technology |
| spelling | doaj.art-06efba30bfe644788d84721e5f6c69002022-12-21T23:50:35ZengTrakia University. Faculty of Agriculture, Stara ZagoraAgricultural Science and Technology1313-88201314-412X2020-09-0112323424010.15547/ast.2020.03.037Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslingsI. Valchev0 К. Stojanchev1N. Nicolov 2R. Binev3Department of Internal Non-Infectious Diseases, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria Department of Internal Non-Infectious Diseases, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria Department of Internal Non-Infectious Diseases, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria Department of Internal Non-Infectious Diseases, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria Abstarct. The aim of the present investigation was to evaluate the effects of aflatoxin B1 and Mycotox NG applied either independently or together, on blood total protein, albumin, blood glucose, total bilirubin, triglycerides, cholesterol, enzyme activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), gamma-glutamyl transferase (γ GT), lactate dehydrogenase (LDH) and changes in liver morphology. At the same time, the potential of supplementation of feed with a mycosorbent (Mycotox NG) was evaluated. Experiments were carried out with 40 1-day-old Toulouse geese from mixed sexes divided into one control and three treatment groups (n=10). Groups were as followed: Group I – control (0 mg/kg AFB1 not supplemented with Mycotox NG); Group II (0.5 g/kg Mycotox NG), Group III (0.5 mg/kg AFB1 ) and Group IV (0.5 mg/kg AFB1 and 0.5 g/kg Mycotox NG). In this study, commercially available geese of Toulouse strain were reared from day one to forty two days in the deep litter system of management and the birds were divided into four groups. Normal feed tested free of aflatoxin (AFB1 ), was given to the control (Group - 1). 0.5 g/kg Mycotox was supplemented with the feed to Group 2, Aflatoxin (0.5 mg/ kg feed) was supplemented with the feed to Group 3 and Mycotox Ng (0.5 g/kg feed) + 0.5 mg/kg feed AFB1 was supplemented with the feed to Group 4. The duration of the experiments was 42 days. The monitored blood chemical parameters were analysed on post treatment days 21 and 42. In birds treated only with AFB1, (group III) increased blood activities of studied enzymes. At the same time, blood total protein, albumin, cholesterol, glucose and triglycerides were reduced as compared to controls. The observed histopathological changes in the liver consisted in various extent of dystrophy (congestion, vacuolar and granular dystrophy, round cell proliferation, necrobiotic changes, hyperplasia of gallbladder epithelium). The addition of mycosorbent (Mycotox NG) to the feed of Groups IV reduced substantially the changes in blood chemistry and the severity and frequency of liver histological lesions. The addition of mycosorbent (Mycotox NG) to the feed of Groups IV reduced substantially the changes in blood chemistry and the severity and frequency of liver histological lesions.https://agriscitech.eu/complex-toxin-binder-mycotox-ng-influence-on-the-hepatotoxic-effect-of-aflatoxin-b1-in-experimental-treated-goslings/aflatoxicosis в1chemical parametersliver lesionsmycotox ngtoulouse geese |
| spellingShingle | I. Valchev К. Stojanchev N. Nicolov R. Binev Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings Agricultural Science and Technology aflatoxicosis в1 chemical parameters liver lesions mycotox ng toulouse geese |
| title | Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings |
| title_full | Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings |
| title_fullStr | Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings |
| title_full_unstemmed | Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings |
| title_short | Complex toxin binder mycotox® ng influence on the hepatotoxic effect of aflatoxin B1 in experimental treated goslings |
| title_sort | complex toxin binder mycotox r ng influence on the hepatotoxic effect of aflatoxin b1 in experimental treated goslings |
| topic | aflatoxicosis в1 chemical parameters liver lesions mycotox ng toulouse geese |
| url | https://agriscitech.eu/complex-toxin-binder-mycotox-ng-influence-on-the-hepatotoxic-effect-of-aflatoxin-b1-in-experimental-treated-goslings/ |
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