Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer’s disease

Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer’s disease

Abstract Background In Alzheimer’s disease (AD), fibrillar tau initially occurs locally and progresses preferentially between closely connected regions. However, the underlying sources of regional vulnerability to tau pathology remain unclear. Previous brain-autopsy findings suggest that the myelin...

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Bibliographic Details
Main Authors: Anna Rubinski, Nicolai Franzmeier, Anna Dewenter, Ying Luan, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Martin Dichgans, Oskar Hansson, Michael Ewers, the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Alzheimer’s Research & Therapy
Subjects:
Myelin
Myelin water fraction
Tau-PET
Amyloid-PET
Alzheimer’s disease
Tau spreading
Online Access:https://doi.org/10.1186/s13195-022-01074-9

Internet

https://doi.org/10.1186/s13195-022-01074-9

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