Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction
Objective: To evaluate the association between smoking and cognitive function in patients with fibromyalgia. Patients and Methods: We surveyed 668 patients with fibromyalgia from May 1, 2012 through November 30, 2013 at a major tertiary referral center. Patients were categorized by smoking status. P...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-03-01
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| Series: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542454818301255 |
| _version_ | 1828201628132442112 |
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| author | Lin Ge, MD Ryan S. D'Souza, MD Terry Oh, MD Ann Vincent, MD Arya B. Mohabbat, MD Jason Eldrige, MD Li Jiang, MD Mary O. Whipple, BA Samantha J. McAllister, BA Zhen Wang, PhD Wenchun Qu, MD, MS, PhD William D. Mauck, MD |
| author_facet | Lin Ge, MD Ryan S. D'Souza, MD Terry Oh, MD Ann Vincent, MD Arya B. Mohabbat, MD Jason Eldrige, MD Li Jiang, MD Mary O. Whipple, BA Samantha J. McAllister, BA Zhen Wang, PhD Wenchun Qu, MD, MS, PhD William D. Mauck, MD |
| author_sort | Lin Ge, MD |
| collection | DOAJ |
| description | Objective: To evaluate the association between smoking and cognitive function in patients with fibromyalgia. Patients and Methods: We surveyed 668 patients with fibromyalgia from May 1, 2012 through November 30, 2013 at a major tertiary referral center. Patients were categorized by smoking status. Primary outcome of interest was cognitive function (MASQ questionnaire), and secondary outcomes included fibromyalgia symptom severity (FIQ-R questionnaire), quality of life (SF-36 questionnaire), fatigue (MFI-20 questionnaire), sleep (MOS-sleep scale), anxiety (GAD-7 questionnaire), and depression (PHQ-9 questionnaire). Independent Students' t-tests and χ2 tests were performed for continuous and categorical variables, respectively. Univariate regression analysis identified variables predictive of outcomes, adjusting for age, gender, body mass index, marital status, and educational level. Results: Ninety-four (14.07%) patients self-identified as smokers. There was an association of lower education level, unmarried status, and younger age in smokers compared with nonsmokers. In the adjusted univariate regression analysis, fibromyalgia smokers reported greater perceived total cognitive dysfunction (P=.009) and greater subscale scores of perceived difficulty in language (P=.03), verbal memory (P=.003), visual-spatial memory (P=.02), and attention (P=.04) compared with nonsmokers with fibromyalgia. For secondary outcomes, smokers with fibromyalgia reported greater severity of fibromyalgia-related symptoms (P=.006), worse quality-of-life index in the mental component scale (P=.02), greater sleep problems (P=.01), and increased anxiety (P=.001) compared with nonsmokers who had fibromyalgia. Conclusion: In patients with fibromyalgia, smoking is a risk factor for cognitive dysfunction. Moreover, smokers with fibromyalgia were more likely to report increased severity of fibromyalgia symptoms, worse quality of life, more sleep problems, and increased anxiety compared with nonsmokers with fibromyalgia. |
| first_indexed | 2024-04-12T11:32:43Z |
| format | Article |
| id | doaj.art-06f2180e9cc54b60bc491d8b95a870b9 |
| institution | Directory Open Access Journal |
| issn | 2542-4548 |
| language | English |
| last_indexed | 2024-04-12T11:32:43Z |
| publishDate | 2019-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| spelling | doaj.art-06f2180e9cc54b60bc491d8b95a870b92022-12-22T03:34:56ZengElsevierMayo Clinic Proceedings: Innovations, Quality & Outcomes2542-45482019-03-01317885Tobacco Use in Fibromyalgia Is Associated With Cognitive DysfunctionLin Ge, MD0Ryan S. D'Souza, MD1Terry Oh, MD2Ann Vincent, MD3Arya B. Mohabbat, MD4Jason Eldrige, MD5Li Jiang, MD6Mary O. Whipple, BA7Samantha J. McAllister, BA8Zhen Wang, PhD9Wenchun Qu, MD, MS, PhD10William D. Mauck, MD11Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN; Department of Rheumatology, Guang An Men Hospital, China Academy of Chinese Medical Science, Beijing, ChinaDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MNDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MNDepartment of Medicine, Mayo Clinic, Rochester, MNDepartment of Medicine, Mayo Clinic, Rochester, MNDepartment of Anesthesiology, Pain Division, Mayo Clinic, Rochester, MNDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MNDepartment of Nursing, Mayo Clinic, Rochester, MNDepartment of Medicine, Mayo Clinic, Rochester, MNDepartment of Nursing, Mayo Clinic, Rochester, MNDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN; Department of Anesthesiology, Pain Division, Mayo Clinic, Rochester, MN; Correspondence: Address to Wenchun Qu, MD, MS, PhD, 200 First St SW, Rochester, MN 55905.Department of Anesthesiology, Pain Division, Mayo Clinic, Rochester, MNObjective: To evaluate the association between smoking and cognitive function in patients with fibromyalgia. Patients and Methods: We surveyed 668 patients with fibromyalgia from May 1, 2012 through November 30, 2013 at a major tertiary referral center. Patients were categorized by smoking status. Primary outcome of interest was cognitive function (MASQ questionnaire), and secondary outcomes included fibromyalgia symptom severity (FIQ-R questionnaire), quality of life (SF-36 questionnaire), fatigue (MFI-20 questionnaire), sleep (MOS-sleep scale), anxiety (GAD-7 questionnaire), and depression (PHQ-9 questionnaire). Independent Students' t-tests and χ2 tests were performed for continuous and categorical variables, respectively. Univariate regression analysis identified variables predictive of outcomes, adjusting for age, gender, body mass index, marital status, and educational level. Results: Ninety-four (14.07%) patients self-identified as smokers. There was an association of lower education level, unmarried status, and younger age in smokers compared with nonsmokers. In the adjusted univariate regression analysis, fibromyalgia smokers reported greater perceived total cognitive dysfunction (P=.009) and greater subscale scores of perceived difficulty in language (P=.03), verbal memory (P=.003), visual-spatial memory (P=.02), and attention (P=.04) compared with nonsmokers with fibromyalgia. For secondary outcomes, smokers with fibromyalgia reported greater severity of fibromyalgia-related symptoms (P=.006), worse quality-of-life index in the mental component scale (P=.02), greater sleep problems (P=.01), and increased anxiety (P=.001) compared with nonsmokers who had fibromyalgia. Conclusion: In patients with fibromyalgia, smoking is a risk factor for cognitive dysfunction. Moreover, smokers with fibromyalgia were more likely to report increased severity of fibromyalgia symptoms, worse quality of life, more sleep problems, and increased anxiety compared with nonsmokers with fibromyalgia.http://www.sciencedirect.com/science/article/pii/S2542454818301255 |
| spellingShingle | Lin Ge, MD Ryan S. D'Souza, MD Terry Oh, MD Ann Vincent, MD Arya B. Mohabbat, MD Jason Eldrige, MD Li Jiang, MD Mary O. Whipple, BA Samantha J. McAllister, BA Zhen Wang, PhD Wenchun Qu, MD, MS, PhD William D. Mauck, MD Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| title | Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction |
| title_full | Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction |
| title_fullStr | Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction |
| title_full_unstemmed | Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction |
| title_short | Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction |
| title_sort | tobacco use in fibromyalgia is associated with cognitive dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S2542454818301255 |
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