Hookworm infection associates with a vaginal Type 1/Type 2 immune signature and increased HPV load

Hookworm infection associates with a vaginal Type 1/Type 2 immune signature and increased HPV load

Helminth infection-driven changes to immunity in the female reproductive tract (FRT) is an immune axis that is currently understudied but can have major implications for the control of FRT infections. Here we address how human hookworm infection associates with vaginal immune profile and risk of Hum...

Full description

Bibliographic Details
Main Authors:	Millicent A. Omondi, Eya H. Kamassa, Gnatoulma Katawa, Christèle N. Tchopba, Celina Vogelbusch, Marijo Parcina, Edlom P. Tchadié, Oukoe M. Amessoudji, Kathrin Arndts, Simplice D. Karou, Yaovi Ameyapoh, Malewé Kolou, Achim Hoerauf, Laura E. Layland, William G. C. Horsnell, Manuel Ritter
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Immunology
Subjects:	helminths hookworm sexually-transmitted diseases HPV - human papillomavirus Immune modulation type 1 and type 2 immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009968/full

Similar Items

Hookworm Infections and Sociodemographic Factors Associated With Female Reproductive Tract Infections in Rural Areas of the Central Region of Togo
by: Adjoa Holali Ameyapoh, et al.
Published: (2021-11-01)

Is a mass drug administration deworming programme for school-aged children enough to reduce the prevalence of soil-transmitted helminths and Schistosoma mansoni in adults: a cross-sectional study from Togo
by: Hombamane Christelle Simfele, et al.
Published: (2024-02-01)

Ethnobotanical survey, anthelmintic effects and cytotoxicity of plants used for treatment of helminthiasis in the Central and Kara regions of Togo
by: Essoham Ataba, et al.
Published: (2020-07-01)

Anti-Th17 and anti-Th2 responses effects of hydro-ethanolic extracts of Aframomum melegueta, Khaya senegalensis and Xylopia aethiopica in hyperreactive onchocerciasis individuals' peripheral blood mononuclear cells.
by: Gnatoulma Katawa, et al.
Published: (2022-04-01)

Walking a thin line between fixation and epitope binding – characterization of antigen retrieval methods suitable for eosinophil and HSV-2 staining in formalin-fixed female reproductive tissue
by: Lisa Marie Wadephul, et al.
Published: (2024-04-01)

Helminth antigens differentially modulate the activation of CD4+ and CD8+ T lymphocytes of convalescent COVID-19 patients in vitro
by: Tomabu Adjobimey, et al.
Published: (2022-06-01)

Impact of the use of GeneXpert on TB diagnosis and anti-TB treatment outcome at health facilities in Addis Ababa, Ethiopia in the post-millennium development years.
by: Desalegn Addise Getahun, et al.
Published: (2023-01-01)

Distinct N-Linked Immunoglobulin G Glycosylation Patterns Are Associated With Chronic Pathology and Asymptomatic Infections in Human Lymphatic Filariasis
by: Tomabu Adjobimey, et al.
Published: (2022-03-01)

Adoptive Transfer of Immune Cells Into RAG2IL-2Rγ-Deficient Mice During Litomosoides sigmodontis Infection: A Novel Approach to Investigate Filarial-Specific Immune Responses
by: Anna Wiszniewsky, et al.
Published: (2021-11-01)

Distinct <i>Schistosoma mansoni</i>-Specific Immunoglobulin Subclasses Are Induced by Different <i>Schistosoma mansoni</i> Stages—A Tool to Decipher <i>Schistosoma mansoni</i> Infection Stages
by: Kathrin Arndts, et al.
Published: (2021-12-01)

Comparison of IgA, IgG, and Neutralizing Antibody Responses Following Immunization With Moderna, BioNTech, AstraZeneca, Sputnik-V, Johnson and Johnson, and Sinopharm’s COVID-19 Vaccines
by: Tomabu Adjobimey, et al.
Published: (2022-06-01)

Impact of Helminth Infections on Female Reproductive Health and Associated Diseases
by: Alisha Chetty, et al.
Published: (2020-11-01)

The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicine.
by: Kenneth Pfarr, et al.
Published: (2005-04-01)

Global Distribution Patterns of Carbapenemase-Encoding Bacteria in a New Light: Clues on a Role for Ethnicity
by: Claudio Neidhöfer, et al.
Published: (2021-06-01)

Negative association between ascaris lumbricoides seropositivity and Covid-19 severity: insights from a study in Benin
by: Tomabu Adjobimey, et al.
Published: (2023-08-01)

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.
by: Gnatoulma Katawa, et al.
Published: (2015-01-01)

Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses
by: Laura E. Layland, et al.
Published: (2015-07-01)

Eosinophils in filarial infections: Inducers of protection or pathology?
by: Alexandra Ehrens, et al.
Published: (2022-10-01)

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals
by: Kathrin Arndts, et al.
Published: (2015-03-01)

Induction of Siglec-FhiCD101hi eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection
by: Alisha Chetty, et al.
Published: (2023-05-01)

Distinct Immune Profiles of Exhausted Effector and Memory CD8+ T Cells in Individuals With Filarial Lymphedema
by: Sacha Horn, et al.
Published: (2021-08-01)

Filarial Lymphedema Patients Are Characterized by Exhausted CD4+ T Cells
by: Sacha Horn, et al.
Published: (2022-01-01)

Reduced Type 2 Innate Lymphocyte Cell Frequencies in Patent <i>Wuchereria bancrofti</i>-Infected Individuals
by: Ruth S. E. Tamadaho, et al.
Published: (2023-04-01)

Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis
by: Ehrens, Alexandra, et al.
Published: (2022-03-01)

ESBL Detection: Comparison of a Commercially Available Chromogenic Test for Third Generation Cephalosporine Resistance and Automated Susceptibility Testing in Enterobactericeae.
by: Mohamed Ramadan El-Jade, et al.
Published: (2016-01-01)

Impact of rifaximin on the frequency and characteristics of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites.
by: Philipp Lutz, et al.
Published: (2014-01-01)

Cloning, expression and functional activity of deoxyhypusine synthase from <it>Plasmodium vivax</it>
by: Nassar Marwa, et al.
Published: (2006-10-01)

Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.
by: Ulrich F Prodjinotho, et al.
Published: (2017-07-01)

AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster
by: Miriam Wilmes, et al.
Published: (2017-08-01)

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.
by: Kathrin Arndts, et al.
Published: (2014-02-01)

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti.
by: Kathrin Arndts, et al.
Published: (2012-01-01)

Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis
by: Jayagopi Surendar, et al.
Published: (2019-10-01)

Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate and adaptive immune responses.
by: Manuel Ritter, et al.
Published: (2018-01-01)

Multivariable Regression Analysis in Schistosoma mansoni-Infected Individuals in the Sudan Reveals Unique Immunoepidemiological Profiles in Uninfected, egg+ and Non-egg+ Infected Individuals.
by: Tayseer Elamin Mohamed Elfaki, et al.
Published: (2016-05-01)

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages.
by: Fabian Gondorf, et al.
Published: (2015-01-01)

Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections
by: Nathalie Loeper, et al.
Published: (2019-05-01)

TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection
by: Buerfent, Benedikt C., et al.
Published: (2019-11-01)

Gastrointestinal Pathogens in Multi-Infected Individuals: A Cluster Analysis of Interaction
by: Joy Backhaus, et al.
Published: (2023-10-01)

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system
by: Frederic Risch, et al.
Published: (2023-06-01)

ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2-/- Mice
by: Julia J. Reichwald, et al.
Published: (2022-06-01)