Selective optogenetic modulation of the PBN terminals in the lateral hypothalamic area and basal forebrain regulates emergence from isoflurane anesthesia in mice

Abstract While the mechanism of general anesthesia has been extensively studied, the underlying neural circuitry has yet to be fully understood. The parabrachial nucleus (PBN) plays a crucial role in modulating wakefulness and promoting arousal from general anesthesia. However, the specific role of...

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Bibliographic Details
Main Authors: Kai Lu, Zhenhuan Wang, Ning Bai, Ziyu Zhao, Xinrong Zhao, Yun He
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Anesthesiology
Subjects:
Online Access:https://doi.org/10.1186/s12871-023-02294-8