Glucuronidation Pathways of 5- and 7-Hydroxypropranolol: Determination of Glucuronide Structures and Enzyme Selectivity

Glucuronidation Pathways of 5- and 7-Hydroxypropranolol: Determination of Glucuronide Structures and Enzyme Selectivity

Propranolol, a non-selective beta-blocker medication, has been utilized in the treatment of cardiovascular diseases for several decades. Its hydroxynaphthyl metabolites have been recognized to possess varying degrees of beta-blocker activity due to the unaltered side-chain. This study achieved the s...

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Bibliographic Details
Main Authors:	Fan Yang, Maxi Wenzel, Matthias Bureik, Maria Kristina Parr
Format:	Article
Language:	English
Published:	MDPI AG 2023-11-01
Series:	Molecules
Subjects:	UGTs hydroxypropranolol glucuronidation enzyme bags drug metabolism structural investigation
Online Access:	https://www.mdpi.com/1420-3049/28/23/7783

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