Preliminary study on the short-term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension
Background: Little is known about immediate responses of blood perfusion to the balloon pulmonary angioplasty (BPA) procedure. Objectives: To investigate the changes in pulmonary perfusion of balloon-dilated vessels and untreated vessels with before, immediately after a single BPA and at follow-up....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-12-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/17534666231212307 |
| _version_ | 1827595381149532160 |
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| author | Peng Hou Hai-Ming Chen Si-Yan Lin Wen-Liang Guo Peng-Hao Chen Jie-Long Lin Xiao-Feng Wu Chun-Li Liu Xin-Lu Wang Cheng Hong |
| author_facet | Peng Hou Hai-Ming Chen Si-Yan Lin Wen-Liang Guo Peng-Hao Chen Jie-Long Lin Xiao-Feng Wu Chun-Li Liu Xin-Lu Wang Cheng Hong |
| author_sort | Peng Hou |
| collection | DOAJ |
| description | Background: Little is known about immediate responses of blood perfusion to the balloon pulmonary angioplasty (BPA) procedure. Objectives: To investigate the changes in pulmonary perfusion of balloon-dilated vessels and untreated vessels with before, immediately after a single BPA and at follow-up. Design: Retrospective single-center cohort study. Methods: Patients who had chronic thromboembolic pulmonary hypertension (CTEPH) and completed the pulmonary perfusion single photon emission computed tomography (SPECT) imaging before, immediately after BPA and at follow-up were included. We evaluated the perfusion defects of both-lung, BPA target (balloon dilated) and non-target (untreated) vessel segments according to Begic 3-point scale in each lung segment. Results: Forty patients (40 BPA procedures) were included and were given next BPA after 89 (62–125) days. The hemodynamic parameters including mPAP, PVR, and RAP were significantly improved after a single BPA. Visual scoring results of pulmonary perfusion imaging in 40 BPAs showed the perfusion defect scores of target vessels reduced from 5.6 ± 2.6 to 4.2 ± 2.2 ( p < 0.001) immediately after BPA, and then further diminished to 3.1 ± 1.9 ( p < 0.001) at follow-up. While in the non-target vessels, the post-BPA perfusion defect scores did not change significantly (13.4 ± 4.7 versus 12.8 ± 4.6, p = 0.182), but tended to decrease at follow-up (12.2 ± 4.2). However, there were 17 BPAs of which the post-BPA perfusion defect scores of non-target vessels increased significantly ( p < 0.001), but decreased at follow-up. Conclusion: In addition to improving the blood perfusion of target vessels, BPA also has a certain effect on the perfusion of some non-target vessels. |
| first_indexed | 2024-03-09T02:52:47Z |
| format | Article |
| id | doaj.art-06f347394e91408db45e5f6f3ebf30d4 |
| institution | Directory Open Access Journal |
| issn | 1753-4666 |
| language | English |
| last_indexed | 2024-03-09T02:52:47Z |
| publishDate | 2023-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-06f347394e91408db45e5f6f3ebf30d42023-12-05T08:33:22ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46662023-12-011710.1177/17534666231212307Preliminary study on the short-term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertensionPeng HouHai-Ming ChenSi-Yan LinWen-Liang GuoPeng-Hao ChenJie-Long LinXiao-Feng WuChun-Li LiuXin-Lu WangCheng HongBackground: Little is known about immediate responses of blood perfusion to the balloon pulmonary angioplasty (BPA) procedure. Objectives: To investigate the changes in pulmonary perfusion of balloon-dilated vessels and untreated vessels with before, immediately after a single BPA and at follow-up. Design: Retrospective single-center cohort study. Methods: Patients who had chronic thromboembolic pulmonary hypertension (CTEPH) and completed the pulmonary perfusion single photon emission computed tomography (SPECT) imaging before, immediately after BPA and at follow-up were included. We evaluated the perfusion defects of both-lung, BPA target (balloon dilated) and non-target (untreated) vessel segments according to Begic 3-point scale in each lung segment. Results: Forty patients (40 BPA procedures) were included and were given next BPA after 89 (62–125) days. The hemodynamic parameters including mPAP, PVR, and RAP were significantly improved after a single BPA. Visual scoring results of pulmonary perfusion imaging in 40 BPAs showed the perfusion defect scores of target vessels reduced from 5.6 ± 2.6 to 4.2 ± 2.2 ( p < 0.001) immediately after BPA, and then further diminished to 3.1 ± 1.9 ( p < 0.001) at follow-up. While in the non-target vessels, the post-BPA perfusion defect scores did not change significantly (13.4 ± 4.7 versus 12.8 ± 4.6, p = 0.182), but tended to decrease at follow-up (12.2 ± 4.2). However, there were 17 BPAs of which the post-BPA perfusion defect scores of non-target vessels increased significantly ( p < 0.001), but decreased at follow-up. Conclusion: In addition to improving the blood perfusion of target vessels, BPA also has a certain effect on the perfusion of some non-target vessels.https://doi.org/10.1177/17534666231212307 |
| spellingShingle | Peng Hou Hai-Ming Chen Si-Yan Lin Wen-Liang Guo Peng-Hao Chen Jie-Long Lin Xiao-Feng Wu Chun-Li Liu Xin-Lu Wang Cheng Hong Preliminary study on the short-term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension Therapeutic Advances in Respiratory Disease |
| title | Preliminary study on the short-term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension |
| title_full | Preliminary study on the short-term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension |
| title_fullStr | Preliminary study on the short-term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension |
| title_full_unstemmed | Preliminary study on the short-term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension |
| title_short | Preliminary study on the short-term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension |
| title_sort | preliminary study on the short term changes of pulmonary perfusion after a single balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension |
| url | https://doi.org/10.1177/17534666231212307 |
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