Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets
Background: prednisolone is a corticosteroid with a very bitter taste acts as anti- anti-inflammatory and immune suppressant drug and it is used at any age. Objective: To improve patient compliance by masking the bitter taste of the drug to be delivered as an orodispersible tablet. Methods: Ext...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2023-10-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2057 |
| _version_ | 1797330311596474368 |
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| author | Hiba mohammed Suza ali Eman B. H. Al-Khedairy |
| author_facet | Hiba mohammed Suza ali Eman B. H. Al-Khedairy |
| author_sort | Hiba mohammed Suza ali |
| collection | DOAJ |
| description |
Background: prednisolone is a corticosteroid with a very bitter taste acts as anti- anti-inflammatory and immune suppressant drug and it is used at any age.
Objective: To improve patient compliance by masking the bitter taste of the drug to be delivered as an orodispersible tablet.
Methods: External ionic gelation using sodium alginate (0.5%w/v) and calcium chloride (1% w/v) in presence of 0.5% w/v carbopol 940 was used to prepare taste masked beads loaded with prednisolone to be compressed as orodispersible tablets.
Results: The bitter taste of was masked by preparing beads composed of 1:1:1 (sodium alginate: Carbopol 940: prednisolone) which released only 0.77 % of the drug in pH 6.8 (pH of oral cavity).
The ODT prepared by direct compression using taste masked beads equivalent to 5 mg PRD, 3% crospovidone, 2% PVP, 1% talc, 1% magnesium stearate and combination of Avcil® PH 102 and mannitol at (1:1) ratio was the optimum formula (T6) with hardness of 3.9± 0.32 kg, , friability 0.45%, thickness 2.5 ± 0.05 mm, % drug content 98.2% ± 1.8, wetting time 18.7 ± 1.3 sec, water absorption 41 ± 2.1%, disintegration time 15.3 ± 0.5 sec. and released only 0.75% ± 0.01 of PRD in an oral pH of 6.8 within one minute (indicating good taste masking). Its release in the stomach (pH 0.1N HCl) and intestine (pH 6.8) was continued for up to two hours.
Conclusion: it can be concluded that the external ionic gelation method successfully masked the bitter taste of prednisolone and can also be formulated as taste-masked orodispersible tablets by the direct compression method.
Received: Jan. 2023
Accepted: May 2023
Published: Oct.2023
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| first_indexed | 2024-03-08T07:18:04Z |
| format | Article |
| id | doaj.art-06f35dcadd454f8b86b82f82f0f66b89 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T07:18:04Z |
| publishDate | 2023-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-06f35dcadd454f8b86b82f82f0f66b892024-02-03T00:04:31ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572023-10-0165310.32007/jfacmedbagdad.2057Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible TabletsHiba mohammed Suza ali0Eman B. H. Al-Khedairy1PharmacistDepartment of Pharmacetues, College of pharmacy/ University of Baghdad. Background: prednisolone is a corticosteroid with a very bitter taste acts as anti- anti-inflammatory and immune suppressant drug and it is used at any age. Objective: To improve patient compliance by masking the bitter taste of the drug to be delivered as an orodispersible tablet. Methods: External ionic gelation using sodium alginate (0.5%w/v) and calcium chloride (1% w/v) in presence of 0.5% w/v carbopol 940 was used to prepare taste masked beads loaded with prednisolone to be compressed as orodispersible tablets. Results: The bitter taste of was masked by preparing beads composed of 1:1:1 (sodium alginate: Carbopol 940: prednisolone) which released only 0.77 % of the drug in pH 6.8 (pH of oral cavity). The ODT prepared by direct compression using taste masked beads equivalent to 5 mg PRD, 3% crospovidone, 2% PVP, 1% talc, 1% magnesium stearate and combination of Avcil® PH 102 and mannitol at (1:1) ratio was the optimum formula (T6) with hardness of 3.9± 0.32 kg, , friability 0.45%, thickness 2.5 ± 0.05 mm, % drug content 98.2% ± 1.8, wetting time 18.7 ± 1.3 sec, water absorption 41 ± 2.1%, disintegration time 15.3 ± 0.5 sec. and released only 0.75% ± 0.01 of PRD in an oral pH of 6.8 within one minute (indicating good taste masking). Its release in the stomach (pH 0.1N HCl) and intestine (pH 6.8) was continued for up to two hours. Conclusion: it can be concluded that the external ionic gelation method successfully masked the bitter taste of prednisolone and can also be formulated as taste-masked orodispersible tablets by the direct compression method. Received: Jan. 2023 Accepted: May 2023 Published: Oct.2023 https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2057Prednisolone, taste masking, external ionic gelation method, sodium alginate- beads, oro- dispersible tablets |
| spellingShingle | Hiba mohammed Suza ali Eman B. H. Al-Khedairy Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets مجلة كلية الطب Prednisolone, taste masking, external ionic gelation method, sodium alginate- beads, oro- dispersible tablets |
| title | Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets |
| title_full | Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets |
| title_fullStr | Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets |
| title_full_unstemmed | Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets |
| title_short | Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets |
| title_sort | formulation and in vitro evaluation of taste masked prednisolone orodispersible tablets |
| topic | Prednisolone, taste masking, external ionic gelation method, sodium alginate- beads, oro- dispersible tablets |
| url | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2057 |
| work_keys_str_mv | AT hibamohammedsuzaali formulationandinvitroevaluationoftastemaskedprednisoloneorodispersibletablets AT emanbhalkhedairy formulationandinvitroevaluationoftastemaskedprednisoloneorodispersibletablets |