The effect of a topical combination of clonidine and pentoxifylline on post-traumatic neuropathic pain patients: study protocol for a randomized, double-blind placebo-controlled trial

The effect of a topical combination of clonidine and pentoxifylline on post-traumatic neuropathic pain patients: study protocol for a randomized, double-blind placebo-controlled trial

Abstract Background First-line pharmacotherapy for neuropathic pain entails the use of systemic antidepressants and anticonvulsants. These drugs are not optimally effective and poorly tolerated, especially for older patients with comorbid conditions. Given the high number of such patients, there is...

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Bibliographic Details
Main Authors: Oli Abate Fulas, André Laferrière, D. Mark A. Ware, Yoram Shir, Terence J. Coderre
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Trials
Subjects:
Topical treatment
Post-traumatic peripheral neuropathic pain
Pentoxifylline
Clonidine
Dynamic mechanical allodynia
Punctate hyperalgesia
Online Access:https://doi.org/10.1186/s13063-021-05088-w

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