Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation Paradigm
The linearity of BOLD responses is a fundamental presumption in most analysis procedures for BOLD fMRI studies. Previous studies have examined the linearity of BOLD signal increments, but less is known about the linearity of BOLD signal decrements. The present study assessed the linearity of both BO...
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2021.541314/full |
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| author | Yun Lin Xi Zhou Yuji Naya Justin L. Gardner Pei Sun Pei Sun Pei Sun |
| author_facet | Yun Lin Xi Zhou Yuji Naya Justin L. Gardner Pei Sun Pei Sun Pei Sun |
| author_sort | Yun Lin |
| collection | DOAJ |
| description | The linearity of BOLD responses is a fundamental presumption in most analysis procedures for BOLD fMRI studies. Previous studies have examined the linearity of BOLD signal increments, but less is known about the linearity of BOLD signal decrements. The present study assessed the linearity of both BOLD signal increments and decrements in the human primary visual cortex using a contrast adaptation paradigm. Results showed that both BOLD signal increments and decrements kept linearity to long stimuli (e.g., 3 s, 6 s), yet, deviated from linearity to transient stimuli (e.g., 1 s). Furthermore, a voxel-wise analysis showed that the deviation patterns were different for BOLD signal increments and decrements: while the BOLD signal increments demonstrated a consistent overestimation pattern, the patterns for BOLD signal decrements varied from overestimation to underestimation. Our results suggested that corrections to deviations from linearity of transient responses should consider the different effects of BOLD signal increments and decrements. |
| first_indexed | 2024-12-16T09:51:10Z |
| format | Article |
| id | doaj.art-06f73f8449f54bd9816c0cf2c8f386fb |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-16T09:51:10Z |
| publishDate | 2021-08-01 |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-06f73f8449f54bd9816c0cf2c8f386fb2022-12-21T22:36:03ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-08-011510.3389/fnhum.2021.541314541314Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation ParadigmYun Lin0Xi Zhou1Yuji Naya2Justin L. Gardner3Pei Sun4Pei Sun5Pei Sun6Department of Psychology, School of Social Sciences, Tsinghua University, Beijing, ChinaDepartment of Psychology, School of Social Sciences, Tsinghua University, Beijing, ChinaSchool of Psychological and Cognitive Sciences, Peking University, Beijing, ChinaDepartment of Psychology, Stanford University, Stanford, CA, United StatesDepartment of Psychology, School of Social Sciences, Tsinghua University, Beijing, ChinaTsinghua Laboratory of Brain and Intelligence, Tsinghua University, Beijing, ChinaLaboratory for Cognitive Brain Mapping, RIKEN Center for Brain Sciences, Wako, JapanThe linearity of BOLD responses is a fundamental presumption in most analysis procedures for BOLD fMRI studies. Previous studies have examined the linearity of BOLD signal increments, but less is known about the linearity of BOLD signal decrements. The present study assessed the linearity of both BOLD signal increments and decrements in the human primary visual cortex using a contrast adaptation paradigm. Results showed that both BOLD signal increments and decrements kept linearity to long stimuli (e.g., 3 s, 6 s), yet, deviated from linearity to transient stimuli (e.g., 1 s). Furthermore, a voxel-wise analysis showed that the deviation patterns were different for BOLD signal increments and decrements: while the BOLD signal increments demonstrated a consistent overestimation pattern, the patterns for BOLD signal decrements varied from overestimation to underestimation. Our results suggested that corrections to deviations from linearity of transient responses should consider the different effects of BOLD signal increments and decrements.https://www.frontiersin.org/articles/10.3389/fnhum.2021.541314/fullfMRIlinearityBOLD signal decrementvisual cortexcontrast adaptation |
| spellingShingle | Yun Lin Xi Zhou Yuji Naya Justin L. Gardner Pei Sun Pei Sun Pei Sun Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation Paradigm Frontiers in Human Neuroscience fMRI linearity BOLD signal decrement visual cortex contrast adaptation |
| title | Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation Paradigm |
| title_full | Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation Paradigm |
| title_fullStr | Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation Paradigm |
| title_full_unstemmed | Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation Paradigm |
| title_short | Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation Paradigm |
| title_sort | voxel wise linearity analysis of increments and decrements in bold responses in human visual cortex using a contrast adaptation paradigm |
| topic | fMRI linearity BOLD signal decrement visual cortex contrast adaptation |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2021.541314/full |
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