The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of Age
Previous studies showed the association between maternal GDM and long-term effects of overweight in offspring. However, the nature of this association in the early postnatal period is still undetermined. The aim of this prospective cohort study was to evaluate whether maternal GDM is associated with...
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2020.608125/full |
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| author | Qinwen Du Yishai Sompolinsky Asnat Walfisch Huiping Zhong Yan Liu Weiwei Feng |
| author_facet | Qinwen Du Yishai Sompolinsky Asnat Walfisch Huiping Zhong Yan Liu Weiwei Feng |
| author_sort | Qinwen Du |
| collection | DOAJ |
| description | Previous studies showed the association between maternal GDM and long-term effects of overweight in offspring. However, the nature of this association in the early postnatal period is still undetermined. The aim of this prospective cohort study was to evaluate whether maternal GDM is associated with overweight and obesity status in offspring at age 1 year. We studied 1167 infants born at a large obstetrical care hospital including 778 normal glucose tolerance (NGT) and 389 GDM pregnancies, matched in a 1:2 ratio according to offspring’s gender, during the years 2016–2017. Overweight and obesity status in offspring of both groups were evaluated at 1 year of age through questionnaires. Infant outcomes were defined according to the WHO Child Growth Standards based on the length-based BMI-for-age. Female offspring from the GDM group exhibited a higher mean BMI (17.2 vs. 16.6, p < 0.01), a higher rate of obesity (13.9% vs. 7.7%; p < 0.05), and overweight (33.1% vs. 23.5%; p < 0.05) as compared to the NGT female group. In the multivariable regression model, maternal GDM was found to be independently and significantly associated with overweight or obesity in 1-year aged female offspring only (OR 1.61, 95% CI 1.09–2.37, p < 0.05). We found a sex specific association between maternal GDM and the overweight risk only in female offspring at 1 year of age. |
| first_indexed | 2024-12-22T21:43:38Z |
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| id | doaj.art-06f7830b4b994c3fb884d540f279a03d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-22T21:43:38Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-06f7830b4b994c3fb884d540f279a03d2022-12-21T18:11:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-02-011110.3389/fendo.2020.608125608125The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of AgeQinwen Du0Yishai Sompolinsky1Asnat Walfisch2Huiping Zhong3Yan Liu4Weiwei Feng5Department of Gynecology and Obstetrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Obstetrics and Gynecology, Hadassah Mt. Scopus, The Hebrew University, Jerusalem, IsraelDepartment of Obstetrics and Gynecology, Hadassah Mt. Scopus, The Hebrew University, Jerusalem, IsraelDepartment of Gynecology and Obstetrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gynecology and Obstetrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Gynecology and Obstetrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaPrevious studies showed the association between maternal GDM and long-term effects of overweight in offspring. However, the nature of this association in the early postnatal period is still undetermined. The aim of this prospective cohort study was to evaluate whether maternal GDM is associated with overweight and obesity status in offspring at age 1 year. We studied 1167 infants born at a large obstetrical care hospital including 778 normal glucose tolerance (NGT) and 389 GDM pregnancies, matched in a 1:2 ratio according to offspring’s gender, during the years 2016–2017. Overweight and obesity status in offspring of both groups were evaluated at 1 year of age through questionnaires. Infant outcomes were defined according to the WHO Child Growth Standards based on the length-based BMI-for-age. Female offspring from the GDM group exhibited a higher mean BMI (17.2 vs. 16.6, p < 0.01), a higher rate of obesity (13.9% vs. 7.7%; p < 0.05), and overweight (33.1% vs. 23.5%; p < 0.05) as compared to the NGT female group. In the multivariable regression model, maternal GDM was found to be independently and significantly associated with overweight or obesity in 1-year aged female offspring only (OR 1.61, 95% CI 1.09–2.37, p < 0.05). We found a sex specific association between maternal GDM and the overweight risk only in female offspring at 1 year of age.https://www.frontiersin.org/articles/10.3389/fendo.2020.608125/fullin utero hyperglycemiaGDMchildhoodobesityearly postnatal perioddevelopmental origins of healthdevelopmental origins of adult health and disease |
| spellingShingle | Qinwen Du Yishai Sompolinsky Asnat Walfisch Huiping Zhong Yan Liu Weiwei Feng The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of Age Frontiers in Endocrinology in utero hyperglycemia GDM childhoodobesity early postnatal period developmental origins of health developmental origins of adult health and disease |
| title | The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of Age |
| title_full | The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of Age |
| title_fullStr | The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of Age |
| title_full_unstemmed | The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of Age |
| title_short | The Sex Specific Association Between Maternal Gestational Diabetes and Offspring Metabolic Status at 1 Year of Age |
| title_sort | sex specific association between maternal gestational diabetes and offspring metabolic status at 1 year of age |
| topic | in utero hyperglycemia GDM childhoodobesity early postnatal period developmental origins of health developmental origins of adult health and disease |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2020.608125/full |
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