Sex Differences in the Correlation between Fatigue Perception and Regional Gray Matter Volume in Healthy Adults: A Large-Scale Study
The relationship between fatigue perception and regional gray matter volume (rGMV) has seldom been studied in healthy adults. Therefore, this study aimed to analyze sex differences in the correlation between rGMV and fatigue perception using Chalder’s fatigue questionnaire (CFQ). The CFQ was used to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/20/6037 |
| _version_ | 1797472491651727360 |
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| author | Handityo Aulia Putra Kaechang Park Fumio Yamashita |
| author_facet | Handityo Aulia Putra Kaechang Park Fumio Yamashita |
| author_sort | Handityo Aulia Putra |
| collection | DOAJ |
| description | The relationship between fatigue perception and regional gray matter volume (rGMV) has seldom been studied in healthy adults. Therefore, this study aimed to analyze sex differences in the correlation between rGMV and fatigue perception using Chalder’s fatigue questionnaire (CFQ). The CFQ was used to analyze the sexual features of rGMV related to the degree of perceived fatigue in 2955 healthy adults (male = 1560, female = 1395) of various ages (20–89 years, median 56). A higher CFQ score denotes a higher perceived fatigue level by the participant. According to the CFQ scores in males, the volumes of the right orbital part of the inferior frontal gyrus and left precuneus were negatively correlated (i.e., smaller rGMV had a higher CFQ score), whereas the left angular gyrus was positively correlated. In females, the right inferior temporal gyrus was negative, whereas the left middle temporal gyrus and right putamen were positive (i.e., larger rGMV had a higher CFQ score). The lack of identified regions in this large-scale study between males and females might be related to sex differences in clinical or pathological fatigue morbidities. Additionally, the sex differences in the negative or positive correlations between rGMV and fatigue perception may contribute to a better understanding of the neuronal mechanism in the early stages of fatigue development. |
| first_indexed | 2024-03-09T20:02:30Z |
| format | Article |
| id | doaj.art-06f8b95fe89349de8dea595c1c61ba3a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T20:02:30Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-06f8b95fe89349de8dea595c1c61ba3a2023-11-24T00:39:47ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011120603710.3390/jcm11206037Sex Differences in the Correlation between Fatigue Perception and Regional Gray Matter Volume in Healthy Adults: A Large-Scale StudyHandityo Aulia Putra0Kaechang Park1Fumio Yamashita2Research Organization for Regional Alliances, Kochi University of Technology, Kochi 782-8502, JapanResearch Organization for Regional Alliances, Kochi University of Technology, Kochi 782-8502, JapanDivision of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate 028-3694, JapanThe relationship between fatigue perception and regional gray matter volume (rGMV) has seldom been studied in healthy adults. Therefore, this study aimed to analyze sex differences in the correlation between rGMV and fatigue perception using Chalder’s fatigue questionnaire (CFQ). The CFQ was used to analyze the sexual features of rGMV related to the degree of perceived fatigue in 2955 healthy adults (male = 1560, female = 1395) of various ages (20–89 years, median 56). A higher CFQ score denotes a higher perceived fatigue level by the participant. According to the CFQ scores in males, the volumes of the right orbital part of the inferior frontal gyrus and left precuneus were negatively correlated (i.e., smaller rGMV had a higher CFQ score), whereas the left angular gyrus was positively correlated. In females, the right inferior temporal gyrus was negative, whereas the left middle temporal gyrus and right putamen were positive (i.e., larger rGMV had a higher CFQ score). The lack of identified regions in this large-scale study between males and females might be related to sex differences in clinical or pathological fatigue morbidities. Additionally, the sex differences in the negative or positive correlations between rGMV and fatigue perception may contribute to a better understanding of the neuronal mechanism in the early stages of fatigue development.https://www.mdpi.com/2077-0383/11/20/6037regional gray matter volumefatigue perceptionChalder’s fatigue questionnairemyalgic encephalomyelitis/chronic fatigue syndromecoronavirus disease 2019 |
| spellingShingle | Handityo Aulia Putra Kaechang Park Fumio Yamashita Sex Differences in the Correlation between Fatigue Perception and Regional Gray Matter Volume in Healthy Adults: A Large-Scale Study Journal of Clinical Medicine regional gray matter volume fatigue perception Chalder’s fatigue questionnaire myalgic encephalomyelitis/chronic fatigue syndrome coronavirus disease 2019 |
| title | Sex Differences in the Correlation between Fatigue Perception and Regional Gray Matter Volume in Healthy Adults: A Large-Scale Study |
| title_full | Sex Differences in the Correlation between Fatigue Perception and Regional Gray Matter Volume in Healthy Adults: A Large-Scale Study |
| title_fullStr | Sex Differences in the Correlation between Fatigue Perception and Regional Gray Matter Volume in Healthy Adults: A Large-Scale Study |
| title_full_unstemmed | Sex Differences in the Correlation between Fatigue Perception and Regional Gray Matter Volume in Healthy Adults: A Large-Scale Study |
| title_short | Sex Differences in the Correlation between Fatigue Perception and Regional Gray Matter Volume in Healthy Adults: A Large-Scale Study |
| title_sort | sex differences in the correlation between fatigue perception and regional gray matter volume in healthy adults a large scale study |
| topic | regional gray matter volume fatigue perception Chalder’s fatigue questionnaire myalgic encephalomyelitis/chronic fatigue syndrome coronavirus disease 2019 |
| url | https://www.mdpi.com/2077-0383/11/20/6037 |
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