Experimental data of co-crystals of Etravirine and L-tartaric acid
Etravirine is a drug used alongside other medication in the treatment of HIV and is a non-nucleoside reverse transcriptase inhibitor. It is a BCS class IV drug, having low solubility and high permeability (Drugbank, https://www.drugbank.ca/drugs/DB06414) [1]. As a result, large doses of the drug are...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-02-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340917306157 |
| _version_ | 1811281264479567872 |
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| author | Mikal Rekdal Aravind pai Muddukrishna BS |
| author_facet | Mikal Rekdal Aravind pai Muddukrishna BS |
| author_sort | Mikal Rekdal |
| collection | DOAJ |
| description | Etravirine is a drug used alongside other medication in the treatment of HIV and is a non-nucleoside reverse transcriptase inhibitor. It is a BCS class IV drug, having low solubility and high permeability (Drugbank, https://www.drugbank.ca/drugs/DB06414) [1]. As a result, large doses of the drug are required for treatment. Two pills have to be taken twice a day, making it a “pill burden” (Intelence, http://www.intelence.com/hcp/dosing/administration-options) [2]. Therefore, attempts of co-crystallizing Etravirine are attractive as the solubility of the drug tends to increase in this solid form (Schultheiss and Newman, 2009) [3].In this study Etravirine co-crystals were synthesized in the molar ratios 1:1, 1:2 and 2:1 with L-tartaric acid as the co-former. Both slow evaporation and physical mixture was performed to mix the components. DSC values of final products are presented as well as FTIR spectra to observe the altered intermolecular interactions. A chemical stability test was performed after seven days using area under curve data from an HPLC instrument. Keywords: Etravirine, Co-crystals, HPLC, FTIR instrument, DSC instrument |
| first_indexed | 2024-04-13T01:30:30Z |
| format | Article |
| id | doaj.art-06f95f09026448d3946363eaacc58640 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-04-13T01:30:30Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-06f95f09026448d3946363eaacc586402022-12-22T03:08:31ZengElsevierData in Brief2352-34092018-02-0116135140Experimental data of co-crystals of Etravirine and L-tartaric acidMikal Rekdal0Aravind pai1Muddukrishna BS2Department of Chemical Engineering, Norwegian University of Science and Technology, 7491 Trondheim, NorwayDepartment of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India; Corresponding author. Fax: +91 0820 2571998.Etravirine is a drug used alongside other medication in the treatment of HIV and is a non-nucleoside reverse transcriptase inhibitor. It is a BCS class IV drug, having low solubility and high permeability (Drugbank, https://www.drugbank.ca/drugs/DB06414) [1]. As a result, large doses of the drug are required for treatment. Two pills have to be taken twice a day, making it a “pill burden” (Intelence, http://www.intelence.com/hcp/dosing/administration-options) [2]. Therefore, attempts of co-crystallizing Etravirine are attractive as the solubility of the drug tends to increase in this solid form (Schultheiss and Newman, 2009) [3].In this study Etravirine co-crystals were synthesized in the molar ratios 1:1, 1:2 and 2:1 with L-tartaric acid as the co-former. Both slow evaporation and physical mixture was performed to mix the components. DSC values of final products are presented as well as FTIR spectra to observe the altered intermolecular interactions. A chemical stability test was performed after seven days using area under curve data from an HPLC instrument. Keywords: Etravirine, Co-crystals, HPLC, FTIR instrument, DSC instrumenthttp://www.sciencedirect.com/science/article/pii/S2352340917306157 |
| spellingShingle | Mikal Rekdal Aravind pai Muddukrishna BS Experimental data of co-crystals of Etravirine and L-tartaric acid Data in Brief |
| title | Experimental data of co-crystals of Etravirine and L-tartaric acid |
| title_full | Experimental data of co-crystals of Etravirine and L-tartaric acid |
| title_fullStr | Experimental data of co-crystals of Etravirine and L-tartaric acid |
| title_full_unstemmed | Experimental data of co-crystals of Etravirine and L-tartaric acid |
| title_short | Experimental data of co-crystals of Etravirine and L-tartaric acid |
| title_sort | experimental data of co crystals of etravirine and l tartaric acid |
| url | http://www.sciencedirect.com/science/article/pii/S2352340917306157 |
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