Multiple Sclerosis: New Aspects of Immunopathogenesis
Multiple sclerosis (MS) is a multicomponent disease characterized by inflammation, neurodegeneration, and cancellation of the central nervous system recovery mechanisms. The cause of MS is still unknown, but it is undeniable that genetic, environmental and immune factors are involved in the etiopath...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2018-01-01
|
| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/304956 |
| _version_ | 1797207520152911872 |
|---|---|
| author | Ines Lazibat Maja Rubinić Majdak Sven Županić |
| author_facet | Ines Lazibat Maja Rubinić Majdak Sven Županić |
| author_sort | Ines Lazibat |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a multicomponent disease characterized by inflammation, neurodegeneration, and cancellation of the central nervous system recovery mechanisms. The cause of MS is still unknown, but it is undeniable that genetic, environmental and immune factors are involved in the etiopathogenesis of this complex and heterogeneous disease. From the aspect of im-munopathogenesis, until recently the opinion prevailed that autoreactive T lymphocytes played a major role, the activation of which is a key step in MS. The knowledge of the effector and regulatory roles of B cells supports a new concept of MS immunopathogenesis that is based on the highly complex interaction of T and B cells, with B cells actively participating in cellular immunity by directing the intensity and quality of cellular immune response. The mechanisms of B cell activity in MS immunopathogenesis are multiple and include antigen presentation and T cell costimulation, cytokine secretion, antibody synthesis, and formation of ectopic lymphoid B cell aggregates in the intrameningeal spaces. The importance of B cells has been confirmed by modern therapeutic options for the treatment of MS. |
| first_indexed | 2024-04-24T09:24:13Z |
| format | Article |
| id | doaj.art-06fadcc4ab06494183f99ab6f7d8e626 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:24:13Z |
| publishDate | 2018-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-06fadcc4ab06494183f99ab6f7d8e6262024-04-15T15:07:40ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512018-01-0157.2.35236010.20471/acc.2018.57.02.17Multiple Sclerosis: New Aspects of ImmunopathogenesisInes Lazibat0Maja Rubinić Majdak1Sven Županić2Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Dubrava University Hospital, Zagreb, CroatiaDubrava University Hospital, Zagreb, CroatiaDubrava University Hospital, Zagreb, CroatiaMultiple sclerosis (MS) is a multicomponent disease characterized by inflammation, neurodegeneration, and cancellation of the central nervous system recovery mechanisms. The cause of MS is still unknown, but it is undeniable that genetic, environmental and immune factors are involved in the etiopathogenesis of this complex and heterogeneous disease. From the aspect of im-munopathogenesis, until recently the opinion prevailed that autoreactive T lymphocytes played a major role, the activation of which is a key step in MS. The knowledge of the effector and regulatory roles of B cells supports a new concept of MS immunopathogenesis that is based on the highly complex interaction of T and B cells, with B cells actively participating in cellular immunity by directing the intensity and quality of cellular immune response. The mechanisms of B cell activity in MS immunopathogenesis are multiple and include antigen presentation and T cell costimulation, cytokine secretion, antibody synthesis, and formation of ectopic lymphoid B cell aggregates in the intrameningeal spaces. The importance of B cells has been confirmed by modern therapeutic options for the treatment of MS.https://hrcak.srce.hr/file/304956Multiple SclerosisInflammationT-LymphocytesB-LymphocytesImmunity, Cellular |
| spellingShingle | Ines Lazibat Maja Rubinić Majdak Sven Županić Multiple Sclerosis: New Aspects of Immunopathogenesis Acta Clinica Croatica Multiple Sclerosis Inflammation T-Lymphocytes B-Lymphocytes Immunity, Cellular |
| title | Multiple Sclerosis: New Aspects of Immunopathogenesis |
| title_full | Multiple Sclerosis: New Aspects of Immunopathogenesis |
| title_fullStr | Multiple Sclerosis: New Aspects of Immunopathogenesis |
| title_full_unstemmed | Multiple Sclerosis: New Aspects of Immunopathogenesis |
| title_short | Multiple Sclerosis: New Aspects of Immunopathogenesis |
| title_sort | multiple sclerosis new aspects of immunopathogenesis |
| topic | Multiple Sclerosis Inflammation T-Lymphocytes B-Lymphocytes Immunity, Cellular |
| url | https://hrcak.srce.hr/file/304956 |
| work_keys_str_mv | AT ineslazibat multiplesclerosisnewaspectsofimmunopathogenesis AT majarubinicmajdak multiplesclerosisnewaspectsofimmunopathogenesis AT svenzupanic multiplesclerosisnewaspectsofimmunopathogenesis |