Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk

Identification of Inhibitors of Integrin Cytoplasmic Domain Interactions With Syk

Leukocyte inflammatory responses require integrin cell-adhesion molecule signaling through spleen tyrosine kinase (Syk), a non-receptor kinase that binds directly to integrin β-chain cytoplasmic domains. Here, we developed a high-throughput screen to identify small molecule inhibitors of the Syk-int...

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Bibliographic Details
Main Authors: Deenadayalan Bakthavatsalam, John W. Craft, Anna Kazansky, Nghi Nguyen, Goeun Bae, Amy R. Caivano, C. William Gundlach, Asra Aslam, Safa Ali, Shashikant Gupta, Sophie Y. Lin, Hema D. Parthiban, Peter Vanderslice, Clifford C. Stephan, Darren G. Woodside
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
inflammation
cell adhesion
integrin
signaling
tyrosine kinase
immune response receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.575085/full

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