Expression of the SARS-CoV-2 receptorACE2 in human heart is associated with uncontrolled diabetes, obesity, and activation of the renin angiotensin system

Expression of the SARS-CoV-2 receptorACE2 in human heart is associated with uncontrolled diabetes, obesity, and activation of the renin angiotensin system

Abstract Background Diabetic and obese patients are at higher risk of severe disease and cardiac injury in corona virus 2 (SARS-CoV-2) infections. Cellular entry of SARS-CoV-2 is mainly via the angiotensin-converting enzyme 2 (ACE2) receptor, which is highly expressed in normal hearts. There is a di...

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Bibliographic Details
Main Authors: Michal Herman-Edelstein, Tali Guetta, Amir Barnea, Maayan Waldman, Naomi Ben-Dor, Yaron Barak, Ran Kornowski, Michael Arad, Edith Hochhauser, Dan Aravot
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cardiovascular Diabetology
Subjects:
Corona virus 2 (SARS-CoV-2)
Angiotensin-converting enzyme 2 receptor (ACE2)
Heart
Diabetes
Renin–angiotensin system blockers
Online Access:https://doi.org/10.1186/s12933-021-01275-w

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