Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea
Background/AimsThe incidence of symptomatic hepatitis A reportedly increased among 20- to 40-year-old Korean during the late 2000s. Vaccination against hepatitis A was commenced in the late 1990s and was extended to children aged <10 years. In the present study we analyzed the changes in the sero...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2014-06-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-20-162.pdf |
| _version_ | 1818947148874514432 |
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| author | Sung Jun Chung Tae Yeob Kim Sun Min Kim Min Roh Mi Yeon Yu Jung Hoon Lee ChangKyo Oh Eun Young Lee Seung Lee Yong Cheol Jeon Kyo-Sang Yoo Joo Hyun Sohn |
| author_facet | Sung Jun Chung Tae Yeob Kim Sun Min Kim Min Roh Mi Yeon Yu Jung Hoon Lee ChangKyo Oh Eun Young Lee Seung Lee Yong Cheol Jeon Kyo-Sang Yoo Joo Hyun Sohn |
| author_sort | Sung Jun Chung |
| collection | DOAJ |
| description | Background/AimsThe incidence of symptomatic hepatitis A reportedly increased among 20- to 40-year-old Korean during the late 2000s. Vaccination against hepatitis A was commenced in the late 1990s and was extended to children aged <10 years. In the present study we analyzed the changes in the seroprevalence of IgG anti-hepatitis A virus (HAV) over the past 13 years.MethodsOverall, 4903 subjects who visited our hospital between January 2001 and December 2013 were studied. The seroprevalence of IgG anti-HAV was analyzed according to age and sex. In addition, the seroprevalence of IgG anti-HAV was compared among 12 age groups and among the following time periods: early 2000s (2001-2003), mid-to-late 2000s (2006-2008), and early 2010s (2011-2013). The chi-square test for trend was used for statistical analysis.ResultsThe seroprevalence of IgG anti-HAV did not differ significantly between the sexes. Furthermore, compared to the seroprevalence of IgG anti-HAV in the early 2000s and mid-to-late 2000s, that in the early 2010s was markedly increased among individuals aged 1-14 years and decreased among those aged 25-44 years (P<0.01). We also found that the seroprevalence of IgG anti-HAV in individuals aged 25-44 years in the early 2010s was lower than that in the early 2000s and mid-to-late 2000s.ConclusionsThe number of symptomatic HAV infection cases in Korea is decreasing, but the seroprevalence of IgG anti-HAV is low in the active population. |
| first_indexed | 2024-12-20T08:26:18Z |
| format | Article |
| id | doaj.art-0700286728a046fb83610174eefe9cf5 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-20T08:26:18Z |
| publishDate | 2014-06-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-0700286728a046fb83610174eefe9cf52022-12-21T19:46:49ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2014-06-0120216216710.3350/cmh.2014.20.2.1621074Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in KoreaSung Jun Chung0Tae Yeob Kim1Sun Min Kim2Min Roh3Mi Yeon Yu4Jung Hoon Lee5ChangKyo Oh6Eun Young Lee7Seung Lee8Yong Cheol Jeon9Kyo-Sang Yoo10Joo Hyun Sohn11Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Background/AimsThe incidence of symptomatic hepatitis A reportedly increased among 20- to 40-year-old Korean during the late 2000s. Vaccination against hepatitis A was commenced in the late 1990s and was extended to children aged <10 years. In the present study we analyzed the changes in the seroprevalence of IgG anti-hepatitis A virus (HAV) over the past 13 years.MethodsOverall, 4903 subjects who visited our hospital between January 2001 and December 2013 were studied. The seroprevalence of IgG anti-HAV was analyzed according to age and sex. In addition, the seroprevalence of IgG anti-HAV was compared among 12 age groups and among the following time periods: early 2000s (2001-2003), mid-to-late 2000s (2006-2008), and early 2010s (2011-2013). The chi-square test for trend was used for statistical analysis.ResultsThe seroprevalence of IgG anti-HAV did not differ significantly between the sexes. Furthermore, compared to the seroprevalence of IgG anti-HAV in the early 2000s and mid-to-late 2000s, that in the early 2010s was markedly increased among individuals aged 1-14 years and decreased among those aged 25-44 years (P<0.01). We also found that the seroprevalence of IgG anti-HAV in individuals aged 25-44 years in the early 2010s was lower than that in the early 2000s and mid-to-late 2000s.ConclusionsThe number of symptomatic HAV infection cases in Korea is decreasing, but the seroprevalence of IgG anti-HAV is low in the active population.http://e-cmh.org/upload/pdf/cmh-20-162.pdfHepatitis A virusIgG Anti-HAVSeroprevalence |
| spellingShingle | Sung Jun Chung Tae Yeob Kim Sun Min Kim Min Roh Mi Yeon Yu Jung Hoon Lee ChangKyo Oh Eun Young Lee Seung Lee Yong Cheol Jeon Kyo-Sang Yoo Joo Hyun Sohn Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea Clinical and Molecular Hepatology Hepatitis A virus IgG Anti-HAV Seroprevalence |
| title | Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea |
| title_full | Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea |
| title_fullStr | Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea |
| title_full_unstemmed | Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea |
| title_short | Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea |
| title_sort | changes in the seroprevalence of igg anti hepatitis a virus between 2001 and 2013 experience at a single center in korea |
| topic | Hepatitis A virus IgG Anti-HAV Seroprevalence |
| url | http://e-cmh.org/upload/pdf/cmh-20-162.pdf |
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