Risk factors for early postoperative cognitive dysfunction after colorectal surgery
Abstract Background It has been reported that postoperative cognitive dysfunction (POCD) is correlated with the degeneration of the central nervous system, oxidative stress, inflammation, and endocrine and immune dysfunction. Increased age, predisposed comorbidity, long surgery time, and prolonged s...
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12871-018-0676-4 |
| _version_ | 1828885951466700800 |
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| author | Yuan Zhang Hong-Guang Bao Yun-Luo Lv Yan-Na Si Liu Han Hong-Yu Wang Yu-Jie Gao Wei-Qing Jiang Chen Zhang |
| author_facet | Yuan Zhang Hong-Guang Bao Yun-Luo Lv Yan-Na Si Liu Han Hong-Yu Wang Yu-Jie Gao Wei-Qing Jiang Chen Zhang |
| author_sort | Yuan Zhang |
| collection | DOAJ |
| description | Abstract Background It has been reported that postoperative cognitive dysfunction (POCD) is correlated with the degeneration of the central nervous system, oxidative stress, inflammation, and endocrine and immune dysfunction. Increased age, predisposed comorbidity, long surgery time, and prolonged stay in the intensive care unit have been reported to be risk factors for developing POCD for cardiac surgery. In the present study, the risk factors of early POCD after colorectal surgery were investigated. Methods Eighty patients, who provided informed consents for their participation in this study, were enrolled and received colorectal surgery under general anesthesia. Neuropsychological tests were performed preoperatively and on postoperative day seven. The risk factors for POCD were analyzed using a multivariate logistic regression model. Results Nineteen patients were diagnosed with POCD (24.7%). Diabetes history (OR = 8.391 [2.208–31.882], P = 0.012), fasting over 3 days after surgery (OR = 5.236 [1.998–13.721], P = 0.001) and an SIRS score of > 3 on the second day after surgery (OR = 6.995 [1.948–25.111], P = 0.003) were risk factors for early POCD in colorectal cancer patients. Conclusion The risk factors for early POCD after colorectal surgery included diabetes history, fasting over 3 days, and an SIRS score of > 3 on the second day. |
| first_indexed | 2024-12-13T11:36:41Z |
| format | Article |
| id | doaj.art-07009e41858a49298a17b6b084907452 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-13T11:36:41Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-07009e41858a49298a17b6b0849074522022-12-21T23:47:46ZengBMCBMC Anesthesiology1471-22532019-01-011911610.1186/s12871-018-0676-4Risk factors for early postoperative cognitive dysfunction after colorectal surgeryYuan Zhang0Hong-Guang Bao1Yun-Luo Lv2Yan-Na Si3Liu Han4Hong-Yu Wang5Yu-Jie Gao6Wei-Qing Jiang7Chen Zhang8Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Anesthesiology, Nanjing First Hospital, Nanjing Medical UniversityAbstract Background It has been reported that postoperative cognitive dysfunction (POCD) is correlated with the degeneration of the central nervous system, oxidative stress, inflammation, and endocrine and immune dysfunction. Increased age, predisposed comorbidity, long surgery time, and prolonged stay in the intensive care unit have been reported to be risk factors for developing POCD for cardiac surgery. In the present study, the risk factors of early POCD after colorectal surgery were investigated. Methods Eighty patients, who provided informed consents for their participation in this study, were enrolled and received colorectal surgery under general anesthesia. Neuropsychological tests were performed preoperatively and on postoperative day seven. The risk factors for POCD were analyzed using a multivariate logistic regression model. Results Nineteen patients were diagnosed with POCD (24.7%). Diabetes history (OR = 8.391 [2.208–31.882], P = 0.012), fasting over 3 days after surgery (OR = 5.236 [1.998–13.721], P = 0.001) and an SIRS score of > 3 on the second day after surgery (OR = 6.995 [1.948–25.111], P = 0.003) were risk factors for early POCD in colorectal cancer patients. Conclusion The risk factors for early POCD after colorectal surgery included diabetes history, fasting over 3 days, and an SIRS score of > 3 on the second day.http://link.springer.com/article/10.1186/s12871-018-0676-4Postoperative cognitive dysfunctionColorectal surgeryDiabetesFastingSIRS |
| spellingShingle | Yuan Zhang Hong-Guang Bao Yun-Luo Lv Yan-Na Si Liu Han Hong-Yu Wang Yu-Jie Gao Wei-Qing Jiang Chen Zhang Risk factors for early postoperative cognitive dysfunction after colorectal surgery BMC Anesthesiology Postoperative cognitive dysfunction Colorectal surgery Diabetes Fasting SIRS |
| title | Risk factors for early postoperative cognitive dysfunction after colorectal surgery |
| title_full | Risk factors for early postoperative cognitive dysfunction after colorectal surgery |
| title_fullStr | Risk factors for early postoperative cognitive dysfunction after colorectal surgery |
| title_full_unstemmed | Risk factors for early postoperative cognitive dysfunction after colorectal surgery |
| title_short | Risk factors for early postoperative cognitive dysfunction after colorectal surgery |
| title_sort | risk factors for early postoperative cognitive dysfunction after colorectal surgery |
| topic | Postoperative cognitive dysfunction Colorectal surgery Diabetes Fasting SIRS |
| url | http://link.springer.com/article/10.1186/s12871-018-0676-4 |
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