Therapeutic Choices for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: A Systematic Review and Update
(1) Background: Genitourinary syndrome of menopause (GSM) is a medical condition that can affect breast cancer survivors (BCS). This is a complication that often can occur as a result of breast cancer treatment, causing symptoms such as vaginal dryness, itching, burning, dyspareunia, dysuria, pain,...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/4/550 |
| _version_ | 1827744012614762496 |
|---|---|
| author | Lucia Merlino Giulia D’Ovidio Viviana Matys Maria Grazia Piccioni Maria Grazia Porpora Roberto Senatori Maria Federica Viscardi Antonio Vitale Carlo Della Rocca on behalf of Policlinico Umberto I Collaborators |
| author_facet | Lucia Merlino Giulia D’Ovidio Viviana Matys Maria Grazia Piccioni Maria Grazia Porpora Roberto Senatori Maria Federica Viscardi Antonio Vitale Carlo Della Rocca on behalf of Policlinico Umberto I Collaborators |
| author_sort | Lucia Merlino |
| collection | DOAJ |
| description | (1) Background: Genitourinary syndrome of menopause (GSM) is a medical condition that can affect breast cancer survivors (BCS). This is a complication that often can occur as a result of breast cancer treatment, causing symptoms such as vaginal dryness, itching, burning, dyspareunia, dysuria, pain, discomfort, and impairment of sexual function. BCS who experience these symptoms negatively impact multiple aspects of their quality of life to the point that some of them fail to complete adjuvant hormonal treatment; (2) Methods: In this systematic review of the literature, we have analyzed possible pharmacological and non-pharmacological treatments for GSM in BCS. We reviewed systemic hormone therapy, local hormone treatment with estrogens and androgens, the use of vaginal moisturizers and lubricants, ospemifene, and physical therapies such as radiofrequency, electroporation, and vaginal laser; (3) Results: The data available to date demonstrate that the aforementioned treatments are effective for the therapy of GSM and, in particular, vulvovaginal atrophy in BCS. Where possible, combination therapy often appears more useful than using a single line of treatment; (4) Conclusions: We analyzed the efficacy and safety data of each of these options for the treatment of GSM in BCS, emphasizing how often larger clinical trials with longer follow-ups are needed. |
| first_indexed | 2024-03-11T04:38:57Z |
| format | Article |
| id | doaj.art-0700a44e250c4d908882854568b917f3 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T04:38:57Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-0700a44e250c4d908882854568b917f32023-11-17T20:50:31ZengMDPI AGPharmaceuticals1424-82472023-04-0116455010.3390/ph16040550Therapeutic Choices for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: A Systematic Review and UpdateLucia Merlino0Giulia D’Ovidio1Viviana Matys2Maria Grazia Piccioni3Maria Grazia Porpora4Roberto Senatori5Maria Federica Viscardi6Antonio Vitale7Carlo Della Rocca8on behalf of Policlinico Umberto I CollaboratorsDepartment of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, ItalyItalian Society of Colposcopy and Cervicovaginal Pathology (SICPCV), 00186 Rome, ItalyDepartment of Maternal, Infantile and Urological Sciences, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, ItalyComprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Cattolica del Sacro Cuore University, Largo A. Gemelli 8, 00168 Rome, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University, 04100 Latina, Italy(1) Background: Genitourinary syndrome of menopause (GSM) is a medical condition that can affect breast cancer survivors (BCS). This is a complication that often can occur as a result of breast cancer treatment, causing symptoms such as vaginal dryness, itching, burning, dyspareunia, dysuria, pain, discomfort, and impairment of sexual function. BCS who experience these symptoms negatively impact multiple aspects of their quality of life to the point that some of them fail to complete adjuvant hormonal treatment; (2) Methods: In this systematic review of the literature, we have analyzed possible pharmacological and non-pharmacological treatments for GSM in BCS. We reviewed systemic hormone therapy, local hormone treatment with estrogens and androgens, the use of vaginal moisturizers and lubricants, ospemifene, and physical therapies such as radiofrequency, electroporation, and vaginal laser; (3) Results: The data available to date demonstrate that the aforementioned treatments are effective for the therapy of GSM and, in particular, vulvovaginal atrophy in BCS. Where possible, combination therapy often appears more useful than using a single line of treatment; (4) Conclusions: We analyzed the efficacy and safety data of each of these options for the treatment of GSM in BCS, emphasizing how often larger clinical trials with longer follow-ups are needed.https://www.mdpi.com/1424-8247/16/4/550genitourinary syndrome of menopause (GSM)breast cancer survivors (BCS)vulvovaginal atrophy (VVA)aromatase inhibitors (AI)vaginal lubricantsvaginal moisturizers |
| spellingShingle | Lucia Merlino Giulia D’Ovidio Viviana Matys Maria Grazia Piccioni Maria Grazia Porpora Roberto Senatori Maria Federica Viscardi Antonio Vitale Carlo Della Rocca on behalf of Policlinico Umberto I Collaborators Therapeutic Choices for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: A Systematic Review and Update Pharmaceuticals genitourinary syndrome of menopause (GSM) breast cancer survivors (BCS) vulvovaginal atrophy (VVA) aromatase inhibitors (AI) vaginal lubricants vaginal moisturizers |
| title | Therapeutic Choices for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: A Systematic Review and Update |
| title_full | Therapeutic Choices for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: A Systematic Review and Update |
| title_fullStr | Therapeutic Choices for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: A Systematic Review and Update |
| title_full_unstemmed | Therapeutic Choices for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: A Systematic Review and Update |
| title_short | Therapeutic Choices for Genitourinary Syndrome of Menopause (GSM) in Breast Cancer Survivors: A Systematic Review and Update |
| title_sort | therapeutic choices for genitourinary syndrome of menopause gsm in breast cancer survivors a systematic review and update |
| topic | genitourinary syndrome of menopause (GSM) breast cancer survivors (BCS) vulvovaginal atrophy (VVA) aromatase inhibitors (AI) vaginal lubricants vaginal moisturizers |
| url | https://www.mdpi.com/1424-8247/16/4/550 |
| work_keys_str_mv | AT luciamerlino therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT giuliadovidio therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT vivianamatys therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT mariagraziapiccioni therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT mariagraziaporpora therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT robertosenatori therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT mariafedericaviscardi therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT antoniovitale therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT carlodellarocca therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate AT onbehalfofpoliclinicoumbertoicollaborators therapeuticchoicesforgenitourinarysyndromeofmenopausegsminbreastcancersurvivorsasystematicreviewandupdate |