A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study
Background: Statins are the most common drugs used for reducing low-density lipids (LDL). In addition to their lipid-lowering effects, they have well-documented anti-inflammatory actions. The goal of this study was to compare the effects of high dose atorvastatin and rosuvastatin on lipid profiles a...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2021-12-01
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| Series: | Pharmaceutical Sciences |
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| Online Access: | https://ps.tbzmed.ac.ir/PDF/ps-27-568.pdf |
| _version_ | 1831707678662983680 |
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| author | Mahboubeh Darban Elham Yusefabadi Majid MirmohammadKhani Bahram Sohrabi Bahador Bagheri |
| author_facet | Mahboubeh Darban Elham Yusefabadi Majid MirmohammadKhani Bahram Sohrabi Bahador Bagheri |
| author_sort | Mahboubeh Darban |
| collection | DOAJ |
| description | Background: Statins are the most common drugs used for reducing low-density lipids (LDL). In addition to their lipid-lowering effects, they have well-documented anti-inflammatory actions. The goal of this study was to compare the effects of high dose atorvastatin and rosuvastatin on lipid profiles and high sensitivity C Reactive Protein (hs-CRP) in patients undergoing percutaneous coronary intervention (PCI). Methods: The study was done between October 2017 and September 2018 in Semnan KowsarHospital. In this randomized trial, 69 patients with atherosclerotic coronary artery disease were randomly assigned 1:1 to receive atorvastatin (80 mg daily) or rosuvastatin (40 mg daily) for4 months. Levels of hs-CRP and lipid profiles including cholesterol, triglyceride, low-density lipids (LDL), and high-density lipids (HDL) were measured and compared before and after the treatments. Lipid profiles were measured at baseline, 2 months, and 4 months of the treatment. Results: Sixty patients completed the study. The mean age was 61.1 ± 6.6 years with an excess of males. After 4 months, both drugs could significantly reduce LDL levels, however, the between-group differences were not statistically significant. Rosuvastatin significantly increased HDL levels (p < 0.05). In addition, triglyceride levels had a significant reduction in both groups, yet the differences were not significant. Both drugs caused significant reductions in hs-CRP levels(p < 0.05). Moreover, the effects of treatments were seen in drug naïve patients as well as patients who were on statins prior to the trial. Conclusion: The results indicate that high dose therapies with atorvastatin and rosuvastatin have similar effects on lipid profiles and hs-CRP levels in patients undergoing PCI. |
| first_indexed | 2024-12-20T21:45:24Z |
| format | Article |
| id | doaj.art-0700fe16d23d4938a60556a0ae209610 |
| institution | Directory Open Access Journal |
| issn | 2383-2886 |
| language | English |
| last_indexed | 2024-12-20T21:45:24Z |
| publishDate | 2021-12-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical Sciences |
| spelling | doaj.art-0700fe16d23d4938a60556a0ae2096102022-12-21T19:25:42ZengTabriz University of Medical SciencesPharmaceutical Sciences2383-28862021-12-0127456857410.34172/PS.2021.5ps-33409A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized StudyMahboubeh Darban0Elham Yusefabadi1Majid MirmohammadKhani2Bahram Sohrabi3Bahador Bagheri4Department of Internal Medicine, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran.Student Research Committee, Kowsar Hospital, Semnan University of Medical Sciences, Semnan, Iran.Social Determinates of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran.Background: Statins are the most common drugs used for reducing low-density lipids (LDL). In addition to their lipid-lowering effects, they have well-documented anti-inflammatory actions. The goal of this study was to compare the effects of high dose atorvastatin and rosuvastatin on lipid profiles and high sensitivity C Reactive Protein (hs-CRP) in patients undergoing percutaneous coronary intervention (PCI). Methods: The study was done between October 2017 and September 2018 in Semnan KowsarHospital. In this randomized trial, 69 patients with atherosclerotic coronary artery disease were randomly assigned 1:1 to receive atorvastatin (80 mg daily) or rosuvastatin (40 mg daily) for4 months. Levels of hs-CRP and lipid profiles including cholesterol, triglyceride, low-density lipids (LDL), and high-density lipids (HDL) were measured and compared before and after the treatments. Lipid profiles were measured at baseline, 2 months, and 4 months of the treatment. Results: Sixty patients completed the study. The mean age was 61.1 ± 6.6 years with an excess of males. After 4 months, both drugs could significantly reduce LDL levels, however, the between-group differences were not statistically significant. Rosuvastatin significantly increased HDL levels (p < 0.05). In addition, triglyceride levels had a significant reduction in both groups, yet the differences were not significant. Both drugs caused significant reductions in hs-CRP levels(p < 0.05). Moreover, the effects of treatments were seen in drug naïve patients as well as patients who were on statins prior to the trial. Conclusion: The results indicate that high dose therapies with atorvastatin and rosuvastatin have similar effects on lipid profiles and hs-CRP levels in patients undergoing PCI.https://ps.tbzmed.ac.ir/PDF/ps-27-568.pdfrosuvastatinatherosclerosisatorvastatinlipid profilehs-crp |
| spellingShingle | Mahboubeh Darban Elham Yusefabadi Majid MirmohammadKhani Bahram Sohrabi Bahador Bagheri A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study Pharmaceutical Sciences rosuvastatin atherosclerosis atorvastatin lipid profile hs-crp |
| title | A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study |
| title_full | A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study |
| title_fullStr | A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study |
| title_full_unstemmed | A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study |
| title_short | A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study |
| title_sort | comparison on effects of high dose rosuvastatin versus high dose atorvastatin on lipid profile and crp level in patients undergoing percutaneous coronary intervention a randomized study |
| topic | rosuvastatin atherosclerosis atorvastatin lipid profile hs-crp |
| url | https://ps.tbzmed.ac.ir/PDF/ps-27-568.pdf |
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