Immune Complex-Mediated Crescentic Glomerulonephritis
Immune complex-mediated Glomerulonephritis (GN) comprises a group of disorders including Immunoglobulin A (IgA) nephropathy, IgA vasculitis, lupus nephritis, infection-related GN {poststreptococcal, Hepatitis C Virus (HCV)}, and fibrillary GN with polyclonal Immunoglobulin (Ig) deposits. Infection-R...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2022-03-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/16079/52470_CE[Ra1]_F(SHU)_PF1(JY_SS)_PFA(NC_SS)_PN(SHU).pdf |
| _version_ | 1811170384307814400 |
|---|---|
| author | Dhruvi Reddy Siva Ranganthan Green R Hemachandar |
| author_facet | Dhruvi Reddy Siva Ranganthan Green R Hemachandar |
| author_sort | Dhruvi Reddy |
| collection | DOAJ |
| description | Immune complex-mediated Glomerulonephritis (GN) comprises a group of disorders including Immunoglobulin A (IgA) nephropathy, IgA vasculitis, lupus nephritis, infection-related GN {poststreptococcal, Hepatitis C Virus (HCV)}, and fibrillary GN with polyclonal Immunoglobulin (Ig) deposits. Infection-Related Glomerulonephritis (IRGN) is an immune complex-mediated injury which is triggered by an infection other than renal causes. With new evolving histopathological variants such as C3 Glomerulonephritis (C3GN), it can be challenging to consultants in both diagnostic and management aspects in differentiating it from IRGN. It is seen to occur alongside infection in adults with a greater risk of disease progression to End-Stage Renal Disease (ESRD). Here, the authors report a case of 33-year-old male who presented with gastrointestinal and urinary symptoms. Patient was initially diagnosed as infective diarrhoea with Acute Kidney Injury (AKI), and on further evaluation, renal biopsy was suggestive of immune-complex mediated crescentic GN. Patient was treated with steroids and there was an improving trend of renal function and positive outcome after treatment, with an overall good prognosis. Aetiology of this immune-complex mediated crescentic GN is however, unclear due to similarities between Postinfectious Glomerulonephritis (PIGN) and C3 glomerulopathy pathologically. |
| first_indexed | 2024-04-10T16:57:02Z |
| format | Article |
| id | doaj.art-07010e8884c947569e215b8c88571a9d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T16:57:02Z |
| publishDate | 2022-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-07010e8884c947569e215b8c88571a9d2023-02-07T05:21:13ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-03-01163OD01OD0310.7860/JCDR/2022/52470.16079Immune Complex-Mediated Crescentic GlomerulonephritisDhruvi Reddy0Siva Ranganthan Green1R Hemachandar2Resident, Department of Internal Medicine, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.Professor, Department of Internal Medicine, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.Associate Professor, Department of Nephrology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.Immune complex-mediated Glomerulonephritis (GN) comprises a group of disorders including Immunoglobulin A (IgA) nephropathy, IgA vasculitis, lupus nephritis, infection-related GN {poststreptococcal, Hepatitis C Virus (HCV)}, and fibrillary GN with polyclonal Immunoglobulin (Ig) deposits. Infection-Related Glomerulonephritis (IRGN) is an immune complex-mediated injury which is triggered by an infection other than renal causes. With new evolving histopathological variants such as C3 Glomerulonephritis (C3GN), it can be challenging to consultants in both diagnostic and management aspects in differentiating it from IRGN. It is seen to occur alongside infection in adults with a greater risk of disease progression to End-Stage Renal Disease (ESRD). Here, the authors report a case of 33-year-old male who presented with gastrointestinal and urinary symptoms. Patient was initially diagnosed as infective diarrhoea with Acute Kidney Injury (AKI), and on further evaluation, renal biopsy was suggestive of immune-complex mediated crescentic GN. Patient was treated with steroids and there was an improving trend of renal function and positive outcome after treatment, with an overall good prognosis. Aetiology of this immune-complex mediated crescentic GN is however, unclear due to similarities between Postinfectious Glomerulonephritis (PIGN) and C3 glomerulopathy pathologically.https://www.jcdr.net/articles/PDF/16079/52470_CE[Ra1]_F(SHU)_PF1(JY_SS)_PFA(NC_SS)_PN(SHU).pdfacute nephritisc3 glomerulopathychronic kidney diseaseimmunoglobulininfection-related |
| spellingShingle | Dhruvi Reddy Siva Ranganthan Green R Hemachandar Immune Complex-Mediated Crescentic Glomerulonephritis Journal of Clinical and Diagnostic Research acute nephritis c3 glomerulopathy chronic kidney disease immunoglobulin infection-related |
| title | Immune Complex-Mediated Crescentic Glomerulonephritis |
| title_full | Immune Complex-Mediated Crescentic Glomerulonephritis |
| title_fullStr | Immune Complex-Mediated Crescentic Glomerulonephritis |
| title_full_unstemmed | Immune Complex-Mediated Crescentic Glomerulonephritis |
| title_short | Immune Complex-Mediated Crescentic Glomerulonephritis |
| title_sort | immune complex mediated crescentic glomerulonephritis |
| topic | acute nephritis c3 glomerulopathy chronic kidney disease immunoglobulin infection-related |
| url | https://www.jcdr.net/articles/PDF/16079/52470_CE[Ra1]_F(SHU)_PF1(JY_SS)_PFA(NC_SS)_PN(SHU).pdf |
| work_keys_str_mv | AT dhruvireddy immunecomplexmediatedcrescenticglomerulonephritis AT sivaranganthangreen immunecomplexmediatedcrescenticglomerulonephritis AT rhemachandar immunecomplexmediatedcrescenticglomerulonephritis |