Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells
Abstract Macrophages are immune cells with high plasticity that are widely distributed in all tissues and organs of the body. Under the influence of the immune microenvironment of breast tumors, macrophages differentiate into various germline lineages. They exert pro-tumor or tumor-suppressive effec...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01208-y |
| _version_ | 1827633587547013120 |
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| author | XuLing Ji Xiaoxia Huang Chao Li Ningning Guan Tingting Pan Jing Dong Lin Li |
| author_facet | XuLing Ji Xiaoxia Huang Chao Li Ningning Guan Tingting Pan Jing Dong Lin Li |
| author_sort | XuLing Ji |
| collection | DOAJ |
| description | Abstract Macrophages are immune cells with high plasticity that are widely distributed in all tissues and organs of the body. Under the influence of the immune microenvironment of breast tumors, macrophages differentiate into various germline lineages. They exert pro-tumor or tumor-suppressive effects by secreting various cytokines. Pyroptosis is mediated by Gasdermin family proteins, which form holes in cell membranes and cause a violent inflammatory response and cell death. This is an important way for the body to fight off infections. Tumor cell pyroptosis can activate anti-tumor immunity and inhibit tumor growth. At the same time, it releases inflammatory mediators and recruits tumor-associated macrophages (TAMs) for accumulation. Macrophages act as “mediators” of cytokine interactions and indirectly influence the pyroptosis pathway. This paper describes the mechanism of action on the part of TAM in affecting the pyroptosis process of breast tumor cells, as well as its key role in the tumor microenvironment. Additionally, it provides the basis for in-depth research on how to use immune cells to affect breast tumors and guide anti-tumor trends, with important implications for the prevention and treatment of breast tumors. Video Abstract |
| first_indexed | 2024-03-09T15:02:36Z |
| format | Article |
| id | doaj.art-07015a4cdbbc450ab8f7dc07215b35c7 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-09T15:02:36Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-07015a4cdbbc450ab8f7dc07215b35c72023-11-26T13:50:16ZengBMCCell Communication and Signaling1478-811X2023-08-0121111410.1186/s12964-023-01208-yEffect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cellsXuLing Ji0Xiaoxia Huang1Chao Li2Ningning Guan3Tingting Pan4Jing Dong5Lin Li6College of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityAbstract Macrophages are immune cells with high plasticity that are widely distributed in all tissues and organs of the body. Under the influence of the immune microenvironment of breast tumors, macrophages differentiate into various germline lineages. They exert pro-tumor or tumor-suppressive effects by secreting various cytokines. Pyroptosis is mediated by Gasdermin family proteins, which form holes in cell membranes and cause a violent inflammatory response and cell death. This is an important way for the body to fight off infections. Tumor cell pyroptosis can activate anti-tumor immunity and inhibit tumor growth. At the same time, it releases inflammatory mediators and recruits tumor-associated macrophages (TAMs) for accumulation. Macrophages act as “mediators” of cytokine interactions and indirectly influence the pyroptosis pathway. This paper describes the mechanism of action on the part of TAM in affecting the pyroptosis process of breast tumor cells, as well as its key role in the tumor microenvironment. Additionally, it provides the basis for in-depth research on how to use immune cells to affect breast tumors and guide anti-tumor trends, with important implications for the prevention and treatment of breast tumors. Video Abstracthttps://doi.org/10.1186/s12964-023-01208-yTumor-associated macrophagesPyroptosisBreast cancerCytokinesTumor immune microenvironment |
| spellingShingle | XuLing Ji Xiaoxia Huang Chao Li Ningning Guan Tingting Pan Jing Dong Lin Li Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells Cell Communication and Signaling Tumor-associated macrophages Pyroptosis Breast cancer Cytokines Tumor immune microenvironment |
| title | Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells |
| title_full | Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells |
| title_fullStr | Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells |
| title_full_unstemmed | Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells |
| title_short | Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells |
| title_sort | effect of tumor associated macrophages on the pyroptosis of breast cancer tumor cells |
| topic | Tumor-associated macrophages Pyroptosis Breast cancer Cytokines Tumor immune microenvironment |
| url | https://doi.org/10.1186/s12964-023-01208-y |
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