| Summary: | Objective: To evaluate ventricular-arterial coupling (VAC), left ventricular hypertrophy (LVH), diastolic function and arterial stiffness in young and middle-aged men with uncomplicated arterial hypertension
Methods: 97 young men aged 18–27 years (21,2±1,9 years, BP 156,5±14,0/98,5±9,1 mmHg) and 68 middle-aged men aged 40–60 years (n=68, age 53,9±7,2 years, BP 152,7±9,6/94,8±7,8 mmHg) (M) underwent simultaneous EchoCG, blood pressure (BP) and pulse wave velocity measurement. VAC index was calculated arterial elastance (Ea) and left ventricular elastance (Ees) ratio. Ea=end-systolic pressure/stroke volume, Ees=end-systolic pressure/end-systolic volume. LVH was diagnosed if LV mass index was >115 g/m2, Increased arterial stiffness -if PWV >10 m/s, diastolic dysfunction – if E/A <1,0 and E/E’<7 m/s.
Results: In young men Eea 1,86±0,32 and index VAC (0,52±0,10) was similar to that in middle-aged (1,9±0,47 and 0,48±0,19, respectively), despite that Ees in young men was significantly lower (3,67±0,85) than in middle-aged men (4,6±2,1, p<0,01). VAC index <0,5 was found in 34% young men and in 57% middle-aged men (p<0,05), LVH in 7,4% and 67% (p<0,05), diastolic dysfunction 4,1% and 62%, respectively. VAC index was similar in those with and without LVH or diastolic dysfunction in the both age groups. In young men with LVH VAC index was 0,63±0,26, without LVH 0,54±0,12, in middle-aged patients with LVH – 0,45±0,16, without LVH – 0,49±0,21. In young men with diastolic dysfunction VAC index was 0,61±0,13, without diastolic dysfunction – 0,58±0,16. In middle-aged men 0,45±0,14 and 0,48±0,16, respectively. PWV>10 m/s was found in 22,7% of young men and in 80,1% of middle-aged (p<0,05). No significant correlation between VAC index and BP, LVMI, PWV, E/A, E/E’ was found.
Conclusion: Decrease in the VAC index<0,5 indicating LV-arterial uncoupling may be an early marker of cardiovascular remodeling in hypertensive men that may be observed before development of LVH, diastolic dysfunction or increased arterial stiffness.
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